Document Detail

Spontaneous baroreflex measurement in the assessment of cardiac vagal control.
MedLine Citation:
PMID:  15241648     Owner:  NLM     Status:  MEDLINE    
Spontaneous baroreflex sensitivity (SBR) has been suggested to be a measure of tonic parasympathetic cardiac control. The decrease of SBR during vagal inhibition was proven before. In this study, we investigated the response of SBR during vagal activation by administering intravenous atropine and phenylephrine in eight and ten healthy volunteers respectively. Atropine was given at a rate of 0.5 micro g/kg/min for 20 minutes and the infusion rate of phenylephrine was adjusted to increase the blood pressure 20 to 30 mmHg above baseline value. We found that SBR at first increased from 16.9 +/- 9.5 to 41.5 +/- 24.9 ms/mm Hg (p < 0.05) and then decreased to 8.9 +/- 6.2 ms/mm Hg (p < 0.05 compared with the peak value) after the initiation of atropine infusion. SBR also increased significantly (27.2 +/- 12.5 to 49.6 +/- 11.3 ms/mm Hg, p < 0.01) during phenylephrine infusion. The authors propose SBR as a measure of cardiac vagal effect because SBR increases under vagal activation.
Yong-Ping Wang; Ya-Jung Cheng; Chien-Lin Huang
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  14     ISSN:  0959-9851     ISO Abbreviation:  Clin. Auton. Res.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-07-08     Completed Date:  2005-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  189-93     Citation Subset:  IM    
Dept. of Anesthesiology, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan, Republic of China.
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology
Atropine / pharmacology
Baroreflex / drug effects,  physiology*
Blood Pressure / drug effects
Electrocardiography / drug effects
Heart / drug effects,  innervation*,  physiology*
Middle Aged
Muscarinic Antagonists / pharmacology
Phenylephrine / pharmacology
Reference Values
Vagus Nerve / drug effects,  physiology*
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Muscarinic Antagonists; 51-55-8/Atropine; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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