Document Detail

Spontaneous alternation behaviour in rats: kynurenic acid attenuated deficits induced by MK-801.
MedLine Citation:
PMID:  16343655     Owner:  NLM     Status:  MEDLINE    
The present study was undertaken to investigate the effects of pharmacological modulation of the NMDA receptors on spontaneous alternation behaviour. The performance of rats treated with MK-801 and kynurenic acid (KYNA) was assessed in the cross-arm-maze. We evaluated: (a) the total number of arm entries representing locomotor activity, (b) spontaneous variation of different arms thought to reflect alternation performance. In the first experiment, MK-801 (0.01, 0.025, 0.05, 0.1 and 0.2 mg/kg, i.p.) was given 30 min prior to the testing. Beginning the dose of 0.05 mg/kg the drug increased locomotion and impaired alternation performance. An ability of animals to enter subsequently three or four different arms was reduced significantly. In the second experiment, the dose of 0.05 mg/kg was chosen as the lowest possible dose of MK-801 producing marked behavioural impairment. KYNA (0.3, 3 and 30 mg/kg, s.c.) was administered 60 min prior to the MK-801. While all KYNA doses prevented hyperlocomotion, only the highest dose (30 mg/kg) maintained alternation score at the control levels, i.e. the KYNA plus MK-801 treated animals alternated regularly three or four different arms. The results suggest different sensitivity of the two behavioural systems, i.e. locomotion and space orientation, towards pharmacological insult. In conclusion, the study confirmed protective behavioural effects of KYNA given in sufficient amounts and sufficiently long prior MK-801.
Zdenek Hlinák; Ivan Krejcí
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-12-15
Journal Detail:
Title:  Behavioural brain research     Volume:  168     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-01-31     Completed Date:  2006-04-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  144-9     Citation Subset:  IM    
Institute of Physiology, Academy of Sciences of the Czech Republic, Vídenská 1083, 142 20 Prague 4, Czech Republic.
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MeSH Terms
Dizocilpine Maleate / antagonists & inhibitors*,  pharmacology*
Dose-Response Relationship, Drug
Excitatory Amino Acid Antagonists / pharmacology*
Exploratory Behavior / drug effects*
Glutamic Acid / physiology
Kynurenic Acid / pharmacology*
Motor Activity / drug effects*
Nootropic Agents / pharmacology
Piracetam / pharmacology
Rats, Wistar
Reg. No./Substance:
0/Excitatory Amino Acid Antagonists; 0/Nootropic Agents; 492-27-3/Kynurenic Acid; 56-86-0/Glutamic Acid; 7491-74-9/Piracetam; 77086-22-7/Dizocilpine Maleate

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