Document Detail

Spontaneous activity in premature infants affects bone strength.
MedLine Citation:
PMID:  12478448     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Determination of bone strength of lower extremities in very low birth weight (VLBW) premature infants with central nervous system pathology resulting in reduced unilateral spontaneous leg movements. STUDY DESIGN: Quantitative ultrasound (QUS) measurements of speed of sound (SOS) of the tibiae of both legs in three VLBW premature infants with brain insult and unilateral reduced spontaneous activity. Results were compared to QUS measurements of both legs in healthy premature infants. Measurements were performed by the same investigator who was blinded to the clinical course of the participants. RESULTS: Reduced spontaneous activity of one leg due to brain pathology resulted in decreased tibial SOS in the affected side. There was no difference in bone SOS between the legs of the healthy controls. CONCLUSION: Spontaneous movements (mainly antigravity flexion and extension) are important for bone structure and mineralization in VLBW premature infants. QUS may become an important diagnostic modality for the evaluation, treatment, and follow-up of bone strength and osteopenia in this unique population.
Alon Eliakim; Dan Nemet; Orit Friedland; Tzipora Dolfin; Rivka H Regev
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  22     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-12     Completed Date:  2003-04-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  650-2     Citation Subset:  IM    
Department of Pediatrics, Meir Hospital, Kfar Saba, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
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MeSH Terms
Central Nervous System Diseases / pathology,  physiopathology*,  ultrasonography
Gestational Age
Infant, Newborn
Infant, Premature / physiology*
Infant, Premature, Diseases / pathology,  physiopathology*,  ultrasonography
Infant, Very Low Birth Weight / physiology*
Leg / pathology,  physiopathology*,  ultrasonography
Motor Activity / physiology*
Retrospective Studies
Severity of Illness Index
Tibia / pathology,  physiopathology*,  ultrasonography

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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