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Spontaneous Remission of Idiopathic Aldosteronism after long-term treatment with Spironolactone: Results from the German Conn's Registry.
MedLine Citation:
PMID:  21958049     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Context  Primary aldosteronism (PA) is mainly caused by aldosterone producing adenoma and idiopathic bilateral adrenal hyperplasia (IHA). Recently, spontaneous resolution of IHA has been described. Objective  We aimed to determine the frequency of spontaneous remission of PA during long-term treatment with mineralocorticoid receptor (MR) antagonists. Design, Setting, and Patients  37 patients of the Munich PA registry with IHA treated by MR antagonists were investigated. The patients were identified retrospectively by chart review and prospectively assessed by clinical and biochemical means. Main outcome measures  Complete remission of IHA was defined as normal aldosterone to renin ratio, normal suppression test, normalization of hypokalemia in the presence of normal blood pressure. Partial remission was defined as normalization of normal aldosterone to renin ratio, normal suppression test, normalization of hypokalemia in the presence of persistent hypertension. Results  The mean period of MR antagonist treatment was 5.8+0.7 years in the patients. We identified 2 of 37 (5.4%) patients with spontaneous remission, one with complete remission, and one with partial remission. Conclusion  Remission of IHA in PA may occur in some patients after long-term mineralocorticoid antagonist treatment.
Authors:
Evelyn Fischer; Felix Beuschlein; Christoph Degenhart; Philip Jung; Martin Bidlingmaier; Martin Reincke
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-29
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Blackwell Publishing Ltd.
Affiliation:
Medizinische Klinik Innenstadt, Klinikum der Ludwig-Maximilians-Universität München, München Institut für klinische Radiologie, Klinikum der Universität München, München.
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