Document Detail

Spontaneous and PHA-induced rosetting of human blood, tonsil lymphocytes and MLC blasts with sheep, human and horse erythrocytes.
MedLine Citation:
PMID:  136324     Owner:  NLM     Status:  MEDLINE    
Compared to peripheral blood lymphocytes the ability of human tonsil T cells and MLC blasts to bind sheep, human and horse erythrocytes was found to be increased. Tonsil and MLC T cells were able to bind sheep red blood cells without any cold incubation, i.e. they were 'early' rosettes, and higher percentage of human and horse erythrocyte rosettes were formed by these cells. Low doses of phytohaemagglutinin increased the proportion of rosettes between peripheral blood, tonsil, MLC cells and human and horse erythrocytes. PHA acted only on T cells, and not on B cells, lymphoblastoid B and other cell lines. On the ground of the stronger rosetting property of MLC blasts and tonsil cells, it is likely that the T cells responsible for binding of horse and human erythrocytes after PHA treatment are 'early' or 'active' rosetting cells.
P Gergely; F Vanky; E Klein
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  25     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1976 Jul 
Date Detail:
Created Date:  1977-01-25     Completed Date:  1977-01-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  23-7     Citation Subset:  IM    
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MeSH Terms
Cattle / immunology
Cell Line
Erythrocytes / immunology
Horses / immunology
Immunologic Techniques
Lectins / pharmacology
Lymphocyte Culture Test, Mixed
Lymphocytes / immunology*
Palatine Tonsil / immunology
Sheep / immunology
T-Lymphocytes / immunology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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