| Spontaneous Closure of Muscular Trabecular Ventricular Septal Defect: Comparison of Defect Positions. | |
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MedLine Citation:
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PMID: 21517965 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: To evaluate the timing and frequency of spontaneous closure of the muscular trabecular ventricular septal defect (VSD). Methods: We performed a historical cohort study for which 150 patients <3 months of age (median age, 9 days) diagnosed as having a muscular trabecular VSD were selected. Median age at latest follow-up was 2.8 years. Another 32 patients diagnosed after 3 months of age were also reviewed. Using color Doppler, defects were classified into 3 groups: anterior, apical, and midventricular. Results: Spontaneous closure occurred in 126 patients (84%): anterior, 36 of 47 (83%); apical, 26 of 31 (84%); and midventricular, 64 of 72 (89%). Multivariate analyses showed a lower frequency of spontaneous closure for patients of age of ≥20 days at initial echocardiography (hazard ratio 0.60, 95% confidence interval [CI] 0.39 to 0.89) and for anterior and apical muscular trabecular VSD (hazard ratio 0.66, 95% CI 0.47 to 0.95). The prevalence of the midventricular muscular trabecular VSD was significantly lower in patients ≥3 months of age at initial echocardiography than in those <3 months (p = 0.010). Conclusion: We infer that midventricular muscular trabecular VSD tends to close spontaneously earlier and more frequently than either anterior or apical muscular trabecular VSD. |
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Authors:
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Toshiharu Miyake; Tohru Shinohara; Tomohiro Inoue; Satoshi Marutani; Tsukasa Takemura |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-22 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: - ISSN: 1651-2227 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Acta Paediatrica © 2011 Foundation Acta Paediatrica. |
Affiliation:
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Department of Pediatrics, Kinki University School of Medicine, Osakasayama, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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