Document Detail

Spontaneous 51Cr release by isolated rat hepatocytes: an indicator of membrane damage.
MedLine Citation:
PMID:  689706     Owner:  NLM     Status:  MEDLINE    
Radiochromium uptake and release by isolated rat hepatocytes in suspension was monitored under continuous-labeling conditions. Cell protein remained unchanged during the absorption phase, whereas the release of 51Cr correlated well with the loss of cell viability and release of cytoplasmic protein. The results suggest that under equilibrium conditions, 51Cr release represents an efflux of label from damaged or dying preparations and not an elution of radioisotope from intact cells.
R Zawydiwski; R Duncan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vitro     Volume:  14     ISSN:  0073-5655     ISO Abbreviation:  In Vitro     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-12-02     Completed Date:  1978-12-02     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0063733     Medline TA:  In Vitro     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  707-14     Citation Subset:  IM    
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MeSH Terms
Ammonium Chloride / pharmacology
Cell Membrane / metabolism
Cell Survival*
Chromium Radioisotopes / diagnostic use*
Coloring Agents / diagnostic use
Liver / cytology*,  metabolism
Proteins / metabolism
Reg. No./Substance:
0/Chromium Radioisotopes; 0/Coloring Agents; 0/Proteins; 12125-02-9/Ammonium Chloride

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