Document Detail

Spondylodiskitis due to Candida albicans: report of two patients who were successfully treated with fluconazole and review of the literature.
MedLine Citation:
PMID:  8816150     Owner:  NLM     Status:  MEDLINE    
We report the cases of two patients with spondylodiskitis due to Candida albicans who were successfully treated with fluconazole. On the basis of findings from these cases and a review of 52 mycologically proven cases in the literature, we describe the main characteristics of candidal spondylodiskitis. In 60% of the cases, candidal spondylodiskitis was a late complication of candidemia (mean delay, 5.2 months) it was determined to be a complication on the basis of the results of previously positive blood cultures (19 cases), and it was presumed to be a complication in iv drug addicts (12 cases). As spondylodiskitis can be a late complication of candidemia, all episodes of candidemia should be treated with systemic antifungal agents. Clinical and radiological signs of candidal spondylodiskitis were nonspecific. Any bone or joint symptoms in a patient who has had candidemia should be considered to be of fungal origin at the time of presentation. The definitive diagnosis of candidal spondylodiskitis was made on the basis of the results of percutaneous puncture in 26 of 30 cases. The overall prognosis for patients with candidal spondylodiskitis was good, with the full recovery rate ranging from 67% to 100%. The preliminary results of treating candidal spondylodiskitis with triazole derivatives, particularly fluconazole, were satisfactory; there was excellent tolerance of this drug.
C Hennequin; P Bourée; C Hiesse; B Dupont; B Charpentier
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  23     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-27     Completed Date:  1996-12-27     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  176-8     Citation Subset:  IM    
Service de Microbiologie, Hôpital Necker-Enfants Malades, Paris, France.
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MeSH Terms
Antifungal Agents / therapeutic use
Candida albicans / pathogenicity*
Candidiasis / diagnosis,  drug therapy,  etiology*
Discitis / diagnosis,  drug therapy,  etiology*
Fluconazole / therapeutic use
Fungemia / complications
Kidney Transplantation / adverse effects
Liver Cirrhosis, Alcoholic / complications
Middle Aged
Time Factors
Reg. No./Substance:
0/Antifungal Agents; 86386-73-4/Fluconazole

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