| Split immunological tolerance to trophoblast. | |
| | |
MedLine Citation:
|
PMID: 19876828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Split immunological tolerance refers to states in which an individual is capable of mounting certain types of immune responses to a particular antigenic challenge, but is tolerant of the same antigen in other compartments of the immune system. This concept is applicable to the immunological relationship between mother and fetus, and particularly relevant in equine pregnancy. In pregnant mares, antibody responses to paternal foreign Major Histocompatibility Complex class I antigens are robust, while anti-paternal cytotoxic T cell responses are diminished compared to those mounted by non-pregnant mares. Here, we compared the distribution of the major lymphocyte subsets, the percentage of lymphocytes expressing Interferon Gamma (IFNG) and Interleukin 4 (IL4) and the level of expression of the immunoregulatory transcription factor FOXP3 between pregnant and non-pregnant mares, and between peripheral blood and the endometrium during pregnancy. In a cohort of mares in which peripheral blood lymphocytes were tested during early pregnancy and in the non-pregnant state, there were only slight changes observed during pregnancy. In contrast, comparison of peripheral blood lymphocytes with lymphocytes isolated from the endometrial cups of pregnant mares revealed striking differences in lymphocyte sub-populations. The endometrial cups contained higher numbers of IFNG+ lymphocytes, and lower numbers of lymphocytes expressing IL4. The endometrial cup lymphocytes also had higher numbers of FOXP3+ cells compared to peripheral blood lymphocytes. Taken together, these results strengthen the evidence for a state of split tolerance to trophoblast, and furthermore define sharp differences in immune reactivity during equine pregnancy between peripheral blood lymphocytes and lymphocytes at the maternal-fetal interface. |
| | |
Authors:
|
Amanda de Mestre; Leela Noronha; Bettina Wagner; Douglas F Antczak |
Related Documents
:
|
20726788 - Association of monocyte chemotactic protein-1 and cc chemokine receptor 2 gene variants... 8790318 - Prevention of rh isoimmunization after spontaneous, massive fetomaternal hemorrhage. 6519558 - Immunological aspects of pathological pregnancy (infertility immunology). 3083588 - Fetomaternal ab0 incompatibility and erythroblastosis fetalis. 952308 - Instantaneous fetal heart rate monitoring by electromagnetic methods. 2581458 - Pregnancy-induced changes in sheep uterine and carotid arteries. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The International journal of developmental biology Volume: 54 ISSN: 1696-3547 ISO Abbreviation: Int. J. Dev. Biol. Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-01-08 Completed Date: 2010-03-31 Revised Date: 2013-05-31 |
Medline Journal Info:
|
Nlm Unique ID: 8917470 Medline TA: Int J Dev Biol Country: Spain |
Other Details:
|
Languages: eng Pagination: 445-55 Citation Subset: IM |
Affiliation:
|
Department of Veterinary Basic Sciences, The Royal Veterinary College, Royal College Street, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antibody Formation / immunology Endometrium / immunology, metabolism Female Flow Cytometry Forkhead Transcription Factors / genetics, metabolism Histocompatibility Antigens Class I / immunology*, metabolism Horses Immune Tolerance / immunology* Interferon-gamma / metabolism Interleukin-4 / metabolism Organ Specificity / immunology Placenta / immunology* Pregnancy RNA, Messenger / genetics, metabolism Reverse Transcriptase Polymerase Chain Reaction T-Lymphocytes / immunology*, metabolism Trophoblasts / immunology* |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HD049545-01/HD/NICHD NIH HHS; R01 HD049545-02/HD/NICHD NIH HHS; R01 HD049545-03/HD/NICHD NIH HHS; R01 HD049545-04/HD/NICHD NIH HHS; R01 HD049545-05/HD/NICHD NIH HHS; R01-HD049545/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Forkhead Transcription Factors; 0/Histocompatibility Antigens Class I; 0/RNA, Messenger; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The placenta in the integrated physiology of fetal volume control.
Next Document: Functional analysis of grimp, a novel gene required for mesodermal cell proliferation at an initial ...