| Split-face study of topical 23.8% L-ascorbic Acid serum in treating photo-aged skin. | |
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MedLine Citation:
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PMID: 22206077 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: L-ascorbic acid has been widely used to treat photo-aged skin. However, its aqueous formula is prone to oxidation. Therefore, a new formula that contains 23.8% L-ascorbic acid and a chemical penetration enhancer was developed. Objective: Observe the efficacy and safety of topical 23.8% L-ascorbic acid serum on photo-aged skin. Methods: Twenty Chinese women with photo-aged skin were enrolled in this split-face study. They were treated with topical L-ascorbic acid serum with iontophoresis on one side of the face once a day for 2 weeks; the other side of the face was spared treatment through participants' self-control. Changes in photo-aged skin were evaluated using a global evaluation, an overall self-assessment, a spectrophotometer, the phase-shift rapid in vivo measurement of skin (PRIMOS) 3D, and a corneometer. Results: Sixteen of 20 patients (80%) experienced a score decrease of 2 or 3 grades, according to the dermatologist. Fifteen patients (75%) rated their overall satisfaction as excellent or good. Dyspigmentation, surface roughness, and fine lines on the treated side improved significantly. Conclusion: Topical 23.8% L-ascorbic acid serum is effective for the treatment of photo-aged skin and does not cause any obvious side effects. J Drugs Dermatol. 2012;11(1):51-56. |
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Authors:
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Tian-Hua Xu; John Zs Chen; Yuan-Hong Li; Yan Wu; Yao-Jia Luo; Xing-Hua Gao; Hong-Duo Chen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of drugs in dermatology : JDD Volume: 11 ISSN: 1545-9616 ISO Abbreviation: J Drugs Dermatol Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101160020 Medline TA: J Drugs Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 51-6 Citation Subset: IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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