Document Detail


Split centromeric alpha-satellite FISH signals in a whole arm translocation 5p;10p: consequences and implications for interphase FISH studies.
MedLine Citation:
PMID:  16618972     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
This is a case report of an apparently balanced whole arm translocation between the short arms of chromosomes 5 and 10 in which the centromeric alpha-satellite DNA is split between both derivative chromosomes for both probes, leading to abnormal signal patterns. The patient requested preimplantation genetic testing for the unbalanced products of the translocation. However, using centromeric alpha-satellite DNA probes as controls for the subtelomeric-specific probes in interphase was not informative because of the split signals. The ramifications of such variation in the alpha-satellite regions of chromosomes for other interphase FISH tests are discussed.
Authors:
Helen Lawce; Deborah Buckmaster; Ellen Magenis; Susan Olson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Association of Genetic Technologists     Volume:  32     ISSN:  1523-7834     ISO Abbreviation:  J Assoc Genet Technol     Publication Date:  2006  
Date Detail:
Created Date:  2006-04-18     Completed Date:  2007-05-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9807282     Medline TA:  J Assoc Genet Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5-7     Citation Subset:  -    
Affiliation:
Oregon Health and Sciences University, Portland, OR, USA.
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