Document Detail


cis-Acting effects on RNA processing and Drosha cleavage prevent Epstein-Barr virus latency III BHRF1 expression.
MedLine Citation:
PMID:  21697496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In Epstein-Barr virus (EBV) latency III (LTIII) infection, BHRF1 encodes three microRNAs (miRNAs). Herein we report that Drosha cleavage of LTIII BHRF1 RNA and cis-acting splicing effects inhibit splicing and inhibit BHRF1 RNA and protein expression. Evidence shown here supports the view that Drosha cleavage to generate mature miRNAs and cis-acting sequences that prevent mRNA maturation are independent processes that prevent LTIII BHRF1 expression in lymphoblastoid cell lines.
Authors:
Li Xing; Elliott Kieff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-06-22
Journal Detail:
Title:  Journal of virology     Volume:  85     ISSN:  1098-5514     ISO Abbreviation:  J. Virol.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-09     Completed Date:  2011-10-04     Revised Date:  2013-07-09    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8929-39     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. xingli107@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Cell Line
Herpesvirus 4, Human / pathogenicity*
Humans
MicroRNAs / biosynthesis*
RNA Processing, Post-Transcriptional*
Ribonuclease III / metabolism*
Viral Proteins / biosynthesis*
Virus Latency*
Grant Support
ID/Acronym/Agency:
CA085180/CA/NCI NIH HHS; CA131354/CA/NCI NIH HHS; CA47006/CA/NCI NIH HHS; R01 CA047006/CA/NCI NIH HHS; R01 CA085180/CA/NCI NIH HHS; R01 CA131354/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/BHRF1 protein, Human herpesvirus 4; 0/MicroRNAs; 0/Viral Proteins; EC 3.1.26.3/DROSHA protein, human; EC 3.1.26.3/Ribonuclease III
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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