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Splice variants of the Alzheimer's disease beta-secretase, BACE1.
MedLine Citation:
PMID:  23142975     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cleavage of the amyloid precursor protein by enzymes commonly referred to as β- and γ-secretase constitute an important process in the pathogenesis of Alzheimer's disease (AD). The regulation of this process is therefore an important subject of investigation. Numerous sources of endogenous regulation have been identified, and one of these is the relative abundance and regulation of splice variants of the β-secretase, BACE1 (β-site amyloid precursor protein cleaving enzyme 1). In this review, we will briefly discuss the main characteristics of BACE1, review the different variants of this enzyme that have been identified to date, and highlight their possible implication in AD.
Authors:
R M Damian Holsinger; Nelleke Goense; John Bohorquez; Padraig Strappe
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-11
Journal Detail:
Title:  Neurogenetics     Volume:  -     ISSN:  1364-6753     ISO Abbreviation:  Neurogenetics     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709714     Medline TA:  Neurogenetics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Laboratory of Molecular Neuroscience, Brain and Mind Research Institute, The University of Sydney, Camperdown, NSW, 2050, Australia, damian.holsinger@sydney.edu.au.
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