Document Detail

Splenosis and sepsis: The born again spleen provides poor protection.
MedLine Citation:
PMID:  21224728     Owner:  NLM     Status:  Publisher    
Splenosis describes ectopic splenic tissue found in patients after rupture of the spleen. These implants are commonly located on the omentum but can be scattered throughout the body in varying number and size. Although splenosis was first documented over a century ago, the precise mechanism for its development remains unknown. The degree of immunoprotection offered by this tissue remains unclear. Much of the human data is in the form of case reports documenting failure of splenotic tissue to protect against septicemia. Even accessory spleens may not offer complete protection once the primary spleen is removed. This review of the literature demonstrates that no amount of splenosis should be considered protective against overwhelming post-splenectomy infection.
Nathan T Connell; Andrew M Brunner; Christine A Kerr; Fred J Schiffman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-01
Journal Detail:
Title:  Virulence     Volume:  2     ISSN:  2150-5608     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101531386     Medline TA:  Virulence     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Alpert Medical School of Brown University; Providence, RI USA.
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