Document Detail

Splenomegaly in mice following exposure to ambient levels of ozone.
MedLine Citation:
PMID:  4035707     Owner:  NLM     Status:  MEDLINE    
Female strain A/J mice were exposed to 0.31 ppm (608 micrograms/m3) ozone continuously for 103 h every other week for 6 mth. Following an additional period of 5 mth in a filtered air environment, animals were killed and examined for evidence of altered spleen weight. It was observed that animals exposed to ozone had a greater spleen weight, and spleen to body weight ratio than air-breathing controls. In some of the ozone-exposed mice, pronounced splenomegaly was noted. Increased spleen weight appears to be another example of an extrapulmonary effect of ozone inhalation.
C Hassett; M G Mustafa; W F Coulson; R M Elashoff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicology letters     Volume:  26     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-10-17     Completed Date:  1985-10-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  IM; S    
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MeSH Terms
Atmosphere Exposure Chambers
Mice, Inbred A
Organ Size / drug effects
Ozone / toxicity*
Spleen / pathology
Splenomegaly / chemically induced*
Thymus Gland / pathology
Reg. No./Substance:

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