Document Detail

Splenic syndrome at mountain altitudes in sickle cell trait. Its occurrence in nonblack persons.
MedLine Citation:
PMID:  3974118     Owner:  NLM     Status:  MEDLINE    
Six consecutive cases of splenic syndrome at mountain altitudes in persons with sickle cell trait are reported and the literature is reviewed. All six cases occurred in men who experienced the acute onset of severe left-upper-quadrant abdominal pain within 48 hours of arrival in Colorado from lower altitudes. All six patients were phenotypically nonblack. Three patients experienced their symptoms at moderate altitudes of 1,609 to 2,134 m (5,280 to 7,000 ft) above sea level. All recovered with medical management and none required splenectomy, although functional hyposplenia was a sequela in at least one patient. The possibility that nonblack persons with sickle cell trait may be at greater risk than black persons with sickle cell trait for the development of splenic syndrome at moderate altitude is discussed.
P A Lane; J H Githens
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  JAMA     Volume:  253     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-04-25     Completed Date:  1985-04-25     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2251-4     Citation Subset:  AIM; IM    
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MeSH Terms
African Continental Ancestry Group
Anemia, Sickle Cell / physiopathology*
European Continental Ancestry Group
Hemoglobin A / analysis
Hemoglobin, Sickle / analysis
Pain / etiology
Physical Exertion
Sickle Cell Trait / complications,  physiopathology*
Splenic Diseases / etiology*,  radionuclide imaging
Splenic Infarction / etiology,  radionuclide imaging
Reg. No./Substance:
0/Hemoglobin, Sickle; 9034-51-9/Hemoglobin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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