| Splenic regrowth in sickle cell anaemia following hypertransfusion. | |
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MedLine Citation:
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PMID: 9012690 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe five adult patients with sickle cell anaemia (SS) who developed clinical, radiological and histological evidence of splenic regrowth while receiving regular blood transfusions. Five patients, all homozygous SS, range 23-34 years, were commenced on hypertransfusion therapy. Three patients were transfused because of severe recurrent vaso-occlusive crises, one for chronic sickle lung and one in an attempt to prevent deterioration of renal function. The mean duration of hypertransfusion prior to documentation of splenic regrowth was 52 months (range 12-97 months). Two patients developed significant hypersplenism. One patient had clinically-apparent splenomegaly and four patients had splenomegaly documented on ultrasound. Splenic regrowth in hypertransfused adults with sickle cell anaemia is not infrequent and may have important clinical implications. |
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Authors:
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P J Campbell; P O Olatunji; K E Ryan; S C Davies |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of haematology Volume: 96 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1997-02-19 Completed Date: 1997-02-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 77-9 Citation Subset: IM |
Affiliation:
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Department of Haematology, Central Middlesex Hospital, London. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia, Sickle Cell / complications, physiopathology* Blood Transfusion / methods* Female Humans Male Recurrence Spleen / growth & development* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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