Document Detail


Splenic "regeneration" after partial splenectomy for Gaucher disease: histological features.
MedLine Citation:
PMID:  10087989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Partial splenectomy for Gaucher disease is often followed by reenlargement of the splenic remnant. It remains unclear if this process is due to tissue regeneration or to continued deposition of glucocerebroside in the reticuloendothelial system or both. We compared the splenic architecture before and after reenlargement in three cases of failed repeated partial splenectomy after two, six and five years. Using the number of lymphoid follicles per hundred low power fields (LF/LPF) as an arbitrary index, we found that prior to the first operation 18, 20 and 27 lymphoid follicles were present per one hundred low power fields, while at the second operation, the corresponding rates were 11, 15 and 17; in control spleens, an average of 712.5 lymphoid follicles were present in one hundred low power fields. The difference in the LF/LPF ratio before and after reenlargement, led us to speculate that splenic re-enlargement in Gaucher disease is mainly the result of the continued deposition of the glucocerebroside in the reticuloendothelial system of the splenic remnant, though some degree of true regeneration as well cannot be completely ruled out. These findings are compared with animal studies and results for partial splenectomy on humans, performed for trauma. Further studies in patients with Gaucher disease are warranted to better define the underlying mechanism of splenic reenlargement.
Authors:
E Freud; I J Cohen; C Mor; D Golinsky; A Blumenfeld; M Zer
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Blood cells, molecules & diseases     Volume:  24     ISSN:  1079-9796     ISO Abbreviation:  Blood Cells Mol. Dis.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1999-05-03     Completed Date:  1999-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9509932     Medline TA:  Blood Cells Mol Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  309-16     Citation Subset:  IM    
Affiliation:
Department of Pediatric Surgery, Schneider Children's Medical Center of Israel, Petah Tiqva. nsfre@netvision.net.il
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Animals
Child
Dogs
Gaucher Disease / surgery*
Humans
Lymphoid Tissue / pathology
Postoperative Period
Rats
Regeneration*
Reoperation
Retrospective Studies
Spleen / blood supply,  pathology,  physiology*
Splenectomy* / methods
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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