Document Detail

Splenic lymphoma with villus lymphocytes--an uncommon cause for lymphocytosis.
MedLine Citation:
PMID:  9407767     Owner:  NLM     Status:  MEDLINE    
We describe the clinical and laboratory features of four patients who presented with mild to moderate lymphocytosis but with no peripheral lymphadenopathy. These patients in the past, would have been classified as chronic lymphocytic leukaemia (CLL). However, it is now realised that chronic lymphoproliferative disorders are very heterogeneous and the clinical and laboratory features of our patients would support a diagnosis of splenic lymphoma with villus lymphocytes (SLVL) with characteristic morphological features. SLVL usually runs a benign clinical course but symptoms related a benign clinical course but symptoms related to splenomegaly or hypersplenism may be a problem. Splenectomy is considered the treatment of choice in these patients. Two of our patients had splenectomy and the other two patients are on regular follow-up without any specific treatment. It is therefore important to recognise this uncommon condition and also to differentiate it from CLL.
P Kuperan; C P Teo; S M Chong; T C Liu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Singapore medical journal     Volume:  38     ISSN:  0037-5675     ISO Abbreviation:  Singapore Med J     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1998-01-27     Completed Date:  1998-01-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404516     Medline TA:  Singapore Med J     Country:  SINGAPORE    
Other Details:
Languages:  eng     Pagination:  395-8     Citation Subset:  IM    
Haematology Division, National University Hospital, Singapore.
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MeSH Terms
Diagnosis, Differential
Lymphocytes / pathology*
Lymphocytosis / etiology*
Lymphoma / complications*,  pathology
Middle Aged
Splenic Neoplasms / complications*,  pathology
Splenomegaly / etiology

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