| Splenic lymphoma: ferrite-enhanced MR imaging in rats. | |
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MedLine Citation:
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PMID: 3336717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ferrite, a new magnetic resonance (MR) contrast agent, was evaluated in the detection and diagnosis of splenic lymphoma. Before administration of ferrite, normal rat spleens and spleens with diffuse lymphoma showed similar in vitro relaxation times and in vivo MR imaging signal-to-noise ratios (S/N). After the administration of ferrite (50 mumol Fe/kg), the T2 time of lymphomatous spleen was 27.0 msec +/- 2.9 (mean +/- standard deviation), which was significantly greater than that of normal spleen (10.7 msec +/- 1.5, P less than .005). The S/N of ferrite-enhanced in vivo MR images of lymphomatous spleen was 12.4 +/- 0.9, which was significantly greater than normal (5.7 +/- 0.2, P less than .005). Similar experiments with animal models of micronodular lymphoma also demonstrated that ferrite-enhanced MR imaging can distinguish micronodular lymphoma from normal spleen. Benign splenomegaly, studied with an animal model of erythroid hyperplasia, showed ferrite-enhanced MR tissue characteristics that were indistinguishable from those of normal spleen. |
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Authors:
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R Weissleder; D D Stark; E J Rummeny; C C Compton; J T Ferrucci |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Radiology Volume: 166 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1988 Feb |
Date Detail:
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Created Date: 1988-02-23 Completed Date: 1988-02-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 423-30 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, Massachusetts General Hospital, Boston 02114. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ferric Compounds / diagnostic use* Lymphoma / diagnosis* Magnetic Resonance Imaging / methods* Rats Spleen / pathology Splenic Neoplasms / diagnosis* Splenomegaly / diagnosis |
| Chemical | |
Reg. No./Substance:
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0/Ferric Compounds; 1317-54-0/ferrite |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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