| Splenic irradiation for chronic autoimmune thrombocytopenic purpura in patients with contra-indications to splenectomy. | |
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MedLine Citation:
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PMID: 7577635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We treated by splenic irradiation eight patients with chronic idiopathic thrombocytopenic purpura (ITP, seven cases) or secondary autoimmune thrombocytopenic purpura (one case) who had contra-indications to splenectomy. A total dose of 15 Gy was delivered to the spleen, with left kidney protection. One patient had a good durable response (> 1 year); two patients had a good transient response (of 3 months duration) but they responded again to a second course of irradiation; two patients had only partial response, but have required no other treatments for 2 years; the three remaining patients had no response. Side-effects were minor. Therefore splenic irradiation appears to be a therapeutic option in patients with chronic ITP who have contra-indications to splenectomy. |
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Authors:
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M T Caulier; F Darloy; C Rose; G Camier; P Morel; F Bauters; P Fenaux |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: British journal of haematology Volume: 91 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 1995 Sep |
Date Detail:
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Created Date: 1995-12-04 Completed Date: 1995-12-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 208-11 Citation Subset: IM |
Affiliation:
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Service des Maladies du Sang, C.H.U. Lille, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Autoimmune Diseases / radiotherapy* Chronic Disease Humans Prospective Studies Purpura, Thrombocytopenic, Idiopathic / radiotherapy* Spleen / radiation effects* Splenectomy / contraindications* Treatment Outcome |
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