| Splenic infarction and subsequent splenic rupture in a patient with paroxysmal nocturnal hemoglobinuria and heparin-induced thrombocytopenia. | |
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MedLine Citation:
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PMID: 19415735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a patient with paroxysmal nocturnal hemoglobinuria (PNH) and no previous history of thrombosis who presented with hepatic venous thromboses and subsequently developed splenic infarction and rupture requiring splenectomy while on anticoagulation therapy for the hepatic thromboses. The patient's anticoagulation was complicated by heparin-induced thrombocytopenia (HIT) highlighting the unique management challenge presented by PNH in combination with HIT. |
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Authors:
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Heather Magnan; Mark L Kayton; Donna M DiMichele; David J Araten; Nancy A Kernan; Farid Boulad |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric blood & cancer Volume: 53 ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-07-20 Completed Date: 2009-07-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 472-4 Citation Subset: IM |
Copyright Information:
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(c) 2009 Wiley-Liss, Inc. |
Affiliation:
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Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anticoagulants / adverse effects* Female Hemoglobinuria, Paroxysmal / complications* Heparin / adverse effects* Humans Splenic Infarction / etiology* Splenic Rupture / etiology* Thrombocytopenia / complications* |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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