Document Detail

Splenic infarction and subsequent splenic rupture in a patient with paroxysmal nocturnal hemoglobinuria and heparin-induced thrombocytopenia.
MedLine Citation:
PMID:  19415735     Owner:  NLM     Status:  MEDLINE    
We describe a patient with paroxysmal nocturnal hemoglobinuria (PNH) and no previous history of thrombosis who presented with hepatic venous thromboses and subsequently developed splenic infarction and rupture requiring splenectomy while on anticoagulation therapy for the hepatic thromboses. The patient's anticoagulation was complicated by heparin-induced thrombocytopenia (HIT) highlighting the unique management challenge presented by PNH in combination with HIT.
Heather Magnan; Mark L Kayton; Donna M DiMichele; David J Araten; Nancy A Kernan; Farid Boulad
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  53     ISSN:  1545-5017     ISO Abbreviation:  Pediatr Blood Cancer     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-07-20     Completed Date:  2009-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  472-4     Citation Subset:  IM    
Copyright Information:
(c) 2009 Wiley-Liss, Inc.
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
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MeSH Terms
Anticoagulants / adverse effects*
Hemoglobinuria, Paroxysmal / complications*
Heparin / adverse effects*
Splenic Infarction / etiology*
Splenic Rupture / etiology*
Thrombocytopenia / complications*
Reg. No./Substance:
0/Anticoagulants; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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