| Splenic infarction during acute malaria. | |
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MedLine Citation:
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PMID: 15550267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Malaria is the most frequent cause of fever among travellers returning from tropical countries. Each year about 7000 cases are notified in France, of which 90% are due to Plasmodium falciparum. We describe the case of a Caucasian female patient with no previous exposure to malaria in whom splenic infarction occurred during effective antimalarial treatment for initially uncomplicated acute malaria. Management was restricted to close clinical monitoring and analgesia (subcutaneous morphine). Imaging abnormalities resolved within a few months. We found seven other such cases in the literature. All seven patients were younger and splenic infarction occurred later than in the case we describe. Clinical outcome was favourable in all the cases. It is noteworthy that this rare complication can occur despite appropriate antimalarial prophylaxis and treatment. There are no known predictive signs. Clinicians must be aware that left hypochondrial pain occurring during treatment for acute malaria may be due to splenic infarction. |
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Authors:
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Philippe Bonnard; Jean-Baptiste Guiard-Schmid; Michel Develoux; Willy Rozenbaum; Gilles Pialoux |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Transactions of the Royal Society of Tropical Medicine and Hygiene Volume: 99 ISSN: 0035-9203 ISO Abbreviation: Trans. R. Soc. Trop. Med. Hyg. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2004-11-19 Completed Date: 2005-05-12 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7506129 Medline TA: Trans R Soc Trop Med Hyg Country: England |
Other Details:
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Languages: eng Pagination: 82-6 Citation Subset: IM |
Affiliation:
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Service de Maladies Infectieuses et Tropicales, Université Pierre et Marie Curie, Hôpital Tenon (AP-HP), 4 rue de la Chine, 75020 Paris, France. philippe.bonnard@tnn.ap-hop-paris.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Administration, Oral Adult Antimalarials / administration & dosage Female Humans Malaria, Falciparum / complications*, drug therapy, radiography Quinine / administration & dosage Splenic Infarction / etiology*, radiography Tomography, X-Ray Computed / methods |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 130-95-0/Quinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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