| Splenic hypofunction and the spectrum of autoimmune and malignant complications in celiac disease. | |
| | |
MedLine Citation:
|
PMID: 16469678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND & AIMS: We investigated the prevalence of functional hyposplenism in autoimmune disorder (AID)-associated and complicated celiac disease (CD). In addition, because the association between hyposplenism and overwhelming infections caused by Streptococcus pneumoniae in patients with CD is well known, we investigated whether immunoglobulin (Ig)M memory B cells, which are responsible for protection against infections by encapsulated bacteria and require the spleen for their generation and/or survival, mirror the reduced splenic function in CD. METHODS: Peripheral blood samples were collected from 73 adult CD patients (27 with AID, 36 without AID, and 10 with CD-related complications including enteropathy-associated T-cell lymphoma, refractory sprue, and ulcerative jejunoileitis). Thirty-four non-CD patients with AID, 35 healthy volunteers, and 29 splenectomized patients also were studied. Counting of erythrocytes with membrane abnormalities (pitted red cells) was used as an indicator of splenic function, and flow cytometry was performed to analyze peripheral blood B cells. RESULTS: A significantly higher risk for hyposplenism was found in AID-associated CD (59%) and complicated CD (80%) than in uncomplicated CD without AID (19%). In AID-associated CD, the degree of splenic function did not correlate to the duration of gluten-free diet. In AID-associated and complicated CD, the frequency of circulating IgM memory B cells was significantly lower than in CD patients without AID or healthy subjects. A significant inverse correlation between IgM memory B cells and pitted red cells was found in all 73 CD patients. CONCLUSIONS: The prevalence of splenic hypofunction is increased in CD with AID and in complicated CD, and is not related to the duration of gluten-free diet. IgM memory B cells are reduced in AID-associated and complicated CD. This defect, which is related to the impairment of splenic function, might predispose hyposplenic CD patients to infections by encapsulated bacteria. |
| | |
Authors:
|
Antonio Di Sabatino; Maria Manuela Rosado; Paolo Cazzola; Roberta Riboni; Federico Biagi; Rita Carsetti; Gino Roberto Corazza |
Related Documents
:
|
15293968 - Kaposis sarcoma in a nairobi hospital. 10502268 - Expression and antigenicity of human herpesvirus 8 encoded orf59 protein in aids-associ... 2447518 - Detection of htlv-iii-specific igg bands in the csf from a patient with aids and enceph... 3140018 - Nitrite inhalants: historical perspective. 11252208 - Addressing multiple problems in the family practice office visit. 15293968 - Kaposis sarcoma in a nairobi hospital. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Volume: 4 ISSN: 1542-3565 ISO Abbreviation: Clin. Gastroenterol. Hepatol. Publication Date: 2006 Feb |
Date Detail:
|
Created Date: 2006-02-10 Completed Date: 2006-06-06 Revised Date: 2006-09-18 |
Medline Journal Info:
|
Nlm Unique ID: 101160775 Medline TA: Clin Gastroenterol Hepatol Country: United States |
Other Details:
|
Languages: eng Pagination: 179-86 Citation Subset: IM |
Affiliation:
|
First Department of Medicine, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico S. Matteo, University of Pavia, Piazzale Golgi 5, 27100 Pavia, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acquired Immunodeficiency Syndrome
/
complications Adult Aged Autoimmune Diseases / complications* B-Lymphocytes / immunology Celiac Disease / complications, diet therapy, physiopathology* Erythrocytes / pathology Female Humans Immunoglobulin M / immunology Immunologic Memory / immunology Male Middle Aged Prevalence Spleen / physiopathology* Splenectomy |
| Chemical | |
Reg. No./Substance:
|
0/Immunoglobulin M |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Frozen section analysis of esophageal endoscopic mucosal resection specimens in the real-time manage...
Next Document: Health-related quality of life in patients attending a gastroenterology outpatient clinic: functiona...