Document Detail


Splenic erythroid response to friend polycythemia virus: time course in vitro after infection in vivo.
MedLine Citation:
PMID:  875048     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When spleen cells removed from plethoric BALB/c mice shortly after infection with Friend polycythemia virus were cultured, they subsequently increased their rate of hemoglobin synthesis in vitro without the addition of the hormone erythropoietin. The increased 59Fe incorporation into hemoglobin in vitro was part of a well-defined single wave unlike the progressive increase in hemoglobin synthesis that occurs in vivo. The peak occurred within the same total time (85-105 hr after infection), irrespective of either the virus dose or time after infection when the cells were removed from the animal and cultured. However, the magnitude of the peak increased with an increase in either of these two variables. Medium change experiments indicated that the time during which the peak occurred was not artificially determined by depletion of some medium component or the accumulation of an inhibitor. This system may be useful in separating the early events of Friend virus infection from the late effects on erythroid differentiation.
Authors:
W D Hankins; P Rosenblatt; S B Krantz
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the National Cancer Institute     Volume:  59     ISSN:  0027-8874     ISO Abbreviation:  J. Natl. Cancer Inst.     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-08-25     Completed Date:  1977-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503089     Medline TA:  J Natl Cancer Inst     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  107-11     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Division
Cell Transformation, Neoplastic
Culture Media
Erythropoiesis*
Friend murine leukemia virus*
Hemoglobins / biosynthesis
Mice
Mice, Inbred BALB C
Polycythemia / etiology,  metabolism,  physiopathology*
Spleen / metabolism,  physiopathology*
Time Factors
Tumor Virus Infections / physiopathology*
Chemical
Reg. No./Substance:
0/Culture Media; 0/Hemoglobins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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