Document Detail

Splenic angiomatoid nodular transformation in child with inflammatory pseudotumor-like areas.
MedLine Citation:
PMID:  22234124     Owner:  NLM     Status:  MEDLINE    
Reports of sclerosing angiomatoid transformation (SANT) in the pediatric age group are rare. We present a case of SANT in an 11-year-old child with a history of trauma presenting with rapidly growing splenic lesion since 2 months. A partial splenectomy revealed a well-demarcated nodular lesion 5 × 4 × 4 cm with central area of fibrosis. Most part of the lesion showed ill-defined nodules or diffuse areas of plump epithelioid appearing endothelial units that marked with CD31, but the internodular stroma was inflammatory pseudotumor (IPT)-like with a mitotic count of 1-2/10 hpf. The angiomatoid nodules were diffusely positive for CD31, CD163, and CD68; however, they were negative for CD34, CD30, smooth muscle actin, and CD8. Epstein-Barr virus-encoded RNA in situ hybridization (EBER-ISH) was negative. The MIB1 labeling was fairly high in the IPT area but low in the angiomatoid areas. After the diagnosis of SANT, the patient has had an uneventful follow-up for more than 3 years since surgery. The morphologic findings in the case being discussed reaffirm the finding that SANT may have an IPT component and it can be seen even in pediatric age group.
Monika Vyas; Mahesh Deshmukh; Tanuja Shet; Nirmala Jambhekar
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Indian journal of pathology & microbiology     Volume:  54     ISSN:  0974-5130     ISO Abbreviation:  Indian J Pathol Microbiol     Publication Date:    2011 Oct-Dec
Date Detail:
Created Date:  2012-01-11     Completed Date:  2012-04-12     Revised Date:  2014-07-03    
Medline Journal Info:
Nlm Unique ID:  7605904     Medline TA:  Indian J Pathol Microbiol     Country:  India    
Other Details:
Languages:  eng     Pagination:  829-31     Citation Subset:  IM    
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MeSH Terms
Actins / analysis
Antigens, CD / analysis
Granuloma, Plasma Cell / diagnosis*,  pathology*,  surgery
Histiocytoma, Benign Fibrous / diagnosis*,  pathology*,  surgery
Spleen / pathology,  surgery
Splenic Neoplasms / diagnosis*,  pathology*,  surgery
Ubiquitin-Protein Ligases / analysis
Reg. No./Substance:
0/Actins; 0/Antigens, CD; EC ligase, human; EC Ligases

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