Document Detail

Splenectomy for non-haematological metastatic malignant disease.
MedLine Citation:
PMID:  21328018     Owner:  NLM     Status:  Publisher    
PURPOSE: Multiple cases and small series of patients who have undergone splenectomy for metastatic malignant disease have been reported. This study examines the outcome of patients with metastatic malignant disease to the spleen treated by splenectomy at a tertiary oncology centre and a review of cases published in the last 10 years. METHODS: The hospital histopathology database was searched over a 25-year period up to 2004 for patients who had undergone splenectomy for non-haematological malignancy. Medical records of these patients were reviewed and clinical course was examined. The literature review was undertaken using a search of PubMed for the terms "splenectomy" and "metastasis" from 2000 to 2010. RESULTS: Twenty-one cases at our institution were identified. The most common primary site of malignancy was ovary (nine cases), followed by malignant melanoma (three) and pancreas (three). There were two cases of metastatic disease from colonic primary and one each from renal, breast, nasopharyngeal and unknown primary disease. There were two cases of long-term disease-free survival (both primary ovarian tumours) and four cases of patients who survived more than 4 years but had disease recurrence (ovarian and colonic primaries). The literature review provided a further 115 cases. CONCLUSIONS: More favorable outcomes were seen in patients with metachronous disease. There was a trend to improved outcome in ovarian and colorectal primaries over malignant melanoma. It is postulated that improved outcome may be seen in patients for whom there were effective adjuvant chemotherapeutic options, low probability of other metastatic disease and less aggressive tumour biology. However, frequently the presentation is indicative of aggressive widespread disease with a poor prognosis.
Piers A C Gatenby; Satvinder S Mudan; Andrew C Wotherspoon
Related Documents :
1597068 - Ultrastructure of the marginal division in the rat striatum.
22089048 - Popliteal cystic adventitial disease: a case report and literature review.
14695018 - The "homogamy" of road rage: understanding the relationship between victimization and o...
19892628 - Peer review practices in biomedical literature: a time for change?
11815868 - Cutaneous lymphoblastic lymphoma in children: report of six cases with precursor b-cell...
24550078 - Infective endocarditis as a mid-term complication after transcatheter aortic valve impl...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-17
Journal Detail:
Title:  Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie     Volume:  -     ISSN:  1435-2451     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9808285     Medline TA:  Langenbecks Arch Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Academic Department of Surgery, Royal Marsden NHS Foundation Trust, Fulham Road, London, SW3 6JJ, UK,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Flow distribution during infusion of UW and HTK solution in anaesthetised rats.
Next Document:  Simultaneous nailing of skeletal metastases: is the mortality really that high?