| Splenectomy may be a prophylactic treatment for cerebral ischemia? | |
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MedLine Citation:
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PMID: 20381261 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebral ischemia, a phenomenon of reduction in cerebral blood flow, accounts for approximately 80% of all strokes, the third leading cause of death and the leading cause of adult disability. Cerebral ischemia causes heterogeneous changes in tissue oxygenation and cellular metabolism. Focal brain ischemia induces a profound and long-lasting inflammatory reaction which is dominated by macrophages derived from both resident microglia and circulating monocytic precursors. Bone marrow and spleen serve as a reservoir for hematopoietic progenitor cells, especially in rodents. Spleen-derived mononuclear cells home to the site of vascular injury and reduced neointima formation. The migration and engraftment of systematically administered spleen-derived mononuclear cells can be visualized in the post-ischemic brain. Therefore, we hypothesise that removal of the spleen may possibly decrease the production of mononuclear cells, and thus hinder or relieve the inflammatory reaction occured after cerebral ischemia/reperfusion injury. So, the splenectomy may be a prophylactic treatment method for cerebral ischemia. |
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Authors:
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Yusuf Izci |
Publication Detail:
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Type: Journal Article Date: 2010-04-08 |
Journal Detail:
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Title: Medical hypotheses Volume: 75 ISSN: 1532-2777 ISO Abbreviation: Med. Hypotheses Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: United States |
Other Details:
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Languages: eng Pagination: 347-9 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Neurosurgery, Gulhane Military Medical Academy, 06018 Etlik, Ankara, Turkey. yusufizci@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain Ischemia
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complications*,
surgery Cell Movement / physiology* Hematopoietic Stem Cells / cytology Humans Inflammation / etiology*, prevention & control*, surgery Macrophages / immunology* Spleen / cytology* Splenectomy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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