| Splenectomy improves survival by increasing arterial blood supply in a rat model of reduced-size liver. | |
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MedLine Citation:
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PMID: 20302595 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Prevention of acute portal hyperperfusion in small-for-size livers by inflow modulation results in beneficial postoperative outcome. The objective of this study was to unravel the underlying mechanism, emphasizing the intimate relationship between portal venous (PV) and hepatic arterial (HA) blood flow (BF). Rats underwent partial hepatectomy (pHx), splenectomy before pHx or splenectomy and ligation of the A. hepatica before pHx. Portal venous blood flow (PVBF), hepatic arterial blood flow (HABF), and tissue pO₂ were assessed during stepwise resection from 30% to 90%. Hepatic regeneration and hypoxia-responsive gene expression were analyzed in each group after nonlethal 85% pHx. 90% pHx caused a fourfold rise in PVBF, a slight decrease in HABF with a 50% reduction in pO₂, and high mortality. Splenectomy before pHx reduced the PVBF and caused a rise in HABF with doubling in tissue pO₂. An attenuation of hypoxia-responsive gene expression turned into enhanced hepatocellular regeneration and improved survival. A. hepatica ligation abolished the beneficial effect of splenectomy on tissue oxygenation, proliferation, and outcome. In conclusion, the beneficial effect of splenectomy in small-for-size livers can be attributed to a rise in HABF with sufficient oxygen supply rather than to a reduced portal venous hyperperfusion to the remnant liver. |
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Authors:
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Christian Eipel; Kerstin Abshagen; Jessica Ritter; Daniel Cantré; Michael D Menger; Brigitte Vollmar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Transplant international : official journal of the European Society for Organ Transplantation Volume: 23 ISSN: 1432-2277 ISO Abbreviation: Transpl. Int. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8908516 Medline TA: Transpl Int Country: England |
Other Details:
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Languages: eng Pagination: 998-1007 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. Journal compilation © 2010 European Society for Organ Transplantation. |
Affiliation:
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Institute for Experimental Surgery, University of Rostock, Rostock, Germany. eipel@uni-rostock.de |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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