Document Detail

Splenectomy during partial remission in thrombotic thrombocytopenic purpura with prolonged plasma exchange dependency.
MedLine Citation:
PMID:  10467278     Owner:  NLM     Status:  MEDLINE    
Some patients with thrombotic thrombocytopenic purpura (TTP) remain plasma-exchange-dependent for prolonged periods of time. This exposes patients to risk, uses substantial resources, and requires prolonged hospitalization. We have splenectomized 7 such patients following 25-42 plasma exchanges while patients were in partial remission only and were clinically stable. In 6 patients, including 1 with TTP secondary to mitomycin C, thrombocytopenia promptly resolved. Relapse has not occurred during 18 or more months of observation. The seventh patient did not respond. We conclude that splenectomy should be considered as an alternative to continued plasma-exchange therapy in such patients.
M J Mant; A R Turner; D Bruce; C Ritchie; L M Larratt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hematology     Volume:  62     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-09-30     Completed Date:  1999-09-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  56-7     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Wiley-Liss, Inc.
Department of Medicine, Division of Clinical Hematology, University of Alberta, and University of Alberta Hospital, Edmonton, Alberta, Canada.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Antineoplastic Agents / adverse effects
Aspirin / therapeutic use
Combined Modality Therapy
Erythrocyte Transfusion
Mitomycin / adverse effects
Plasma Exchange*
Platelet Aggregation Inhibitors / therapeutic use
Platelet Count
Purpura, Thrombotic Thrombocytopenic / drug therapy,  surgery,  therapy*
Remission Induction
Treatment Outcome
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Antineoplastic Agents; 0/Platelet Aggregation Inhibitors; 50-07-7/Mitomycin; 50-78-2/Aspirin
Comment In:
Am J Hematol. 2000 May;64(1):79   [PMID:  10815796 ]

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