Document Detail

Splenectomized versus non-splenectomized patients with thalassemia major. Echocardiographic comparison.
MedLine Citation:
PMID:  18813418     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the effect of splenectomy in patients with thalassemia major on the cardiovascular system through echocardiographic study. METHODS: A prospective, cross sectional study was carried out from December 2006 to December 2007. Patients from the Thalassemia Center in the Maternity and Children's Hospital, Madina, Kingdom of Saudi Arabia, were screened by means of history, physical examination, laboratory studies, and echocardiography. RESULTS: Fifty-seven patients were studied: 36 were non-splenectomized, while 21 were surgically splenectomized. The 2 study groups were well matched for age, gender, height, and weight. The total amount of blood given during the previous year (6577.1+/-206.9 ml versus 5390.5+/-220.2 ml, p=0.0005), and the annual transfusion index (200.9+/-11.3 versus 134.1+/-7.3, p=0.0001) were significantly lower in the splenectomized group. There was no significant difference between the 2 groups regarding laboratory studies. Left ventricular systolic function shows no difference regarding fraction shortening between the 2 groups. The mitral valve E/A ratio was significantly higher in the splenectomized group (1.6+/-0.2 versus 1.4+/-0.2, p=0.02). The pulmonary artery pressure was higher in the splenectomized group (34.2+/-9.1 versus 20.8+/-9.2 mm Hg, p=0.0001). There was a significantly higher number of patients with pulmonary hypertension in the splenectomized group (14 [66.7%] versus 6 [16.7%], p=0.0004). CONCLUSION: Splenectomized patients with thalassemia major are at high risk of having impaired diastolic left ventricular function and pulmonary hypertension.
Mohamedmofeed F Morsy; Abdulhameed A Alnajjar; Ibrahim S Almuzainy; Zakria M Alhawsawi; Mona H Alserafi; Ali A Ahmed
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Saudi medical journal     Volume:  29     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-24     Completed Date:  2009-01-07     Revised Date:  2009-04-28    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  1310-4     Citation Subset:  IM    
Department of Pediatric Cardiology, Maternity and Children's Hospital, Madina, Kingdom of Saudi Arabia.
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MeSH Terms
Blood Transfusion
Cross-Sectional Studies
Echocardiography, Doppler*
Hypertension, Pulmonary / etiology
Prospective Studies
Splenectomy* / adverse effects
Ventricular Dysfunction, Left / etiology
beta-Thalassemia / surgery*,  ultrasonography*
Comment In:
Saudi Med J. 2009 Mar;30(3):450; author reply 450   [PMID:  19271085 ]
Saudi Med J. 2009 Mar;30(3):451; author reply 451   [PMID:  19271086 ]

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