Document Detail


Spleen volume and blood flow response to repeated breath-hold apneas.
MedLine Citation:
PMID:  12819225     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was 1) to answer whether the reduction in spleen size in breath-hold apnea is an active contraction or a passive collapse secondary to reduced splenic arterial blood flow and 2) to monitor the spleen response to repeated breath-hold apneas. Ten trained apnea divers and 10 intact and 7 splenectomized untrained persons repeated five maximal apneas (A1-A5) with face immersion in cold water, with 2 min interposed between successive attempts. Ultrasonic monitoring of the spleen and noninvasive cardiopulmonary measurements were performed before, between apneas, and at times 0, 10, 20, 40, and 60 min after the last apnea. Blood flows in splenic artery and splenic vein were not significantly affected by breath-hold apnea. The duration of apneas peaked after A3 (143, 127, and 74 s in apnea divers, intact, and splenectomized persons, respectively). A rapid decrease in spleen volume ( approximately 20% in both apnea divers and intact persons) was mainly completed throughout the first apnea. The spleen did not recover in size between apneas and only partly recovered 60 min after A5. The well-known physiological responses to apnea diving, i.e., bradycardia and increased blood pressure, were observed in A1 and remained unchanged throughout the following apneas. These results show rapid, probably active contraction of the spleen in response to breath-hold apnea in humans. Rapid spleen contraction and its slow recovery may contribute to prolongation of successive, briefly repeated apnea attempts.
Authors:
Darija Baković; Zoran Valic; Davor Eterović; Ivica Vukovic; Ante Obad; Ivana Marinović-Terzić; Zeljko Dujić
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-06-20
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  95     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-12     Completed Date:  2004-04-28     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1460-6     Citation Subset:  IM    
Affiliation:
Dept. of Physiology and Biophysics, Univ. of Split School of Medicine, S oltanska 2, 21 000 Split, Croatia. zdujic@bsb.mefst.hr
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MeSH Terms
Descriptor/Qualifier:
Adult
Apnea / blood,  etiology,  physiopathology*,  ultrasonography*
Blood Vessels / ultrasonography
Diving*
Gases / blood
Humans
Male
Reflex
Regional Blood Flow
Respiratory Mechanics*
Spleen / blood supply*,  ultrasonography*
Time Factors
Chemical
Reg. No./Substance:
0/Gases

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