| Spleen neoangiogenesis in patients with myelofibrosis with myeloid metaplasia. | |
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MedLine Citation:
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PMID: 14871248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neoangiogenesis is an integral component of bone marrow myeloproliferation in patients with myelofibrosis with myeloid metaplasia (MMM). As extramedullary haematopoiesis is a constitutive feature of MMM, we studied spleen neoangiogenesis by a computerized image analysis in MMM patients. Compared with five normal subjects, spleen CD34-staining capillary vascular density (CVD) was 2.1-3.03 times higher than the upper range of normal in six of the 15 (40%) MMM patients. CD8-staining sinusoidal vascular density (SVD) was constantly normal or lesser than normal and was inversely correlated with CVD (R = -0.53; P = 0.04). In MMM patients who did not receive cytoreductive or radiation therapy in the month before splenectomy (n = 9), the CVD was a significant determinant of spleen size (R = 0.88; P = 0.04). In MMM patients, the number of spleen CD34+ haematopoietic stem cells was increased from 1.2 to 98 times the upper limit of normal, and predicted the expansion of CVD (R = 0.57; P = 0.03). A population of cells expressing the CD34+/CD133+/VEGFR-2+ angiopoietic phenotype was present in the blood and spleen of five of seven patients. These results document that neoangiogenesis is an integral component of spleen re-localization of haematopoietic stem cells and suggest a cellular mechanism for spleen neoangiogenesis. |
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Authors:
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Giovanni Barosi; Vittorio Rosti; Margherita Massa; Gian Luca Viarengo; Alessandro Pecci; Vittorio Necchi; Isabella Ramaioli; Rita Campanelli; Monia Marchetti; Mario Bazzan; Umberto Magrini |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of haematology Volume: 124 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-02-11 Completed Date: 2004-05-10 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: England |
Other Details:
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Languages: eng Pagination: 618-25 Citation Subset: IM |
Affiliation:
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Laboratory of Medical Informatics, IRCCS Policlinico S. Matteo, Viale Golgi 19, 27100 Pavia, Italy. barosig@smatteo.pv.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antigens, CD34 / analysis Capillaries Female Humans Male Middle Aged Neovascularization, Pathologic / blood, complications, pathology* Primary Myelofibrosis / blood, complications, pathology* Spleen / blood supply* Splenectomy Vascular Endothelial Growth Factor A / blood |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD34; 0/Vascular Endothelial Growth Factor A |
| Comments/Corrections | |
Erratum In:
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Br J Haematol. 2004 Jul;126(2):284-5 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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