| Spleen emptying and venous hematocrit in humans during exercise. | |
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MedLine Citation:
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PMID: 8387068 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The spleen may release pooled erythrocytes to the general circulation during strenuous conditions such as heavy exercise. Most of our knowledge of this reservoir function of the spleen derives from animal studies, and the splenic contribution to the circulating blood volume in humans has been regarded as unimportant. We recorded the erythrocyte content in the human spleen during graded bicycle exercise to maximal working capacity. In five normal adults 99mTc-labeled autologous erythrocytes were injected intravenously, and the subjects were placed on bicycles with the back against a gamma camera focusing on the spleen. During increasing exercise the splenic erythrocyte content decreased linearly, and at maximal work load it had been reduced to a mean of 34.2% (range 44-26%) of the initial count rate at supine rest. Concomitantly norepinephrine and epinephrine in plasma increased gradually, whereas neuropeptide Y increased only at maximal exercise. A rise in hematocrit from a mean of 44.6 to 48 was observed, but the autotransfusion of erythrocytes from the spleen only partly explains the rise in hematocrit during physical activity. |
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Authors:
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M Laub; K Hvid-Jacobsen; P Hovind; I L Kanstrup; N J Christensen; S L Nielsen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 74 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-06-01 Completed Date: 1993-06-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1024-6 Citation Subset: IM |
Affiliation:
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Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, University of Copenhagen, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / physiology Epinephrine / blood Ergometry Erythrocytes / physiology* Exercise / physiology* Female Heart Rate / physiology Hematocrit Hemodynamics / physiology Hemoglobins / metabolism Humans Male Middle Aged Neuropeptide Y / immunology, metabolism Norepinephrine / blood Oxygen Consumption / physiology Regional Blood Flow / physiology Sodium Pertechnetate Tc 99m / diagnostic use Spleen / blood supply*, radionuclide imaging |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Neuropeptide Y; 23288-60-0/Sodium Pertechnetate Tc 99m; 51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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