Document Detail


Spleen emptying and venous hematocrit in humans during exercise.
MedLine Citation:
PMID:  8387068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The spleen may release pooled erythrocytes to the general circulation during strenuous conditions such as heavy exercise. Most of our knowledge of this reservoir function of the spleen derives from animal studies, and the splenic contribution to the circulating blood volume in humans has been regarded as unimportant. We recorded the erythrocyte content in the human spleen during graded bicycle exercise to maximal working capacity. In five normal adults 99mTc-labeled autologous erythrocytes were injected intravenously, and the subjects were placed on bicycles with the back against a gamma camera focusing on the spleen. During increasing exercise the splenic erythrocyte content decreased linearly, and at maximal work load it had been reduced to a mean of 34.2% (range 44-26%) of the initial count rate at supine rest. Concomitantly norepinephrine and epinephrine in plasma increased gradually, whereas neuropeptide Y increased only at maximal exercise. A rise in hematocrit from a mean of 44.6 to 48 was observed, but the autotransfusion of erythrocytes from the spleen only partly explains the rise in hematocrit during physical activity.
Authors:
M Laub; K Hvid-Jacobsen; P Hovind; I L Kanstrup; N J Christensen; S L Nielsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  74     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-06-01     Completed Date:  1993-06-01     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1024-6     Citation Subset:  IM    
Affiliation:
Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, University of Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / physiology
Epinephrine / blood
Ergometry
Erythrocytes / physiology*
Exercise / physiology*
Female
Heart Rate / physiology
Hematocrit
Hemodynamics / physiology
Hemoglobins / metabolism
Humans
Male
Middle Aged
Neuropeptide Y / immunology,  metabolism
Norepinephrine / blood
Oxygen Consumption / physiology
Regional Blood Flow / physiology
Sodium Pertechnetate Tc 99m / diagnostic use
Spleen / blood supply*,  radionuclide imaging
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Neuropeptide Y; 23288-60-0/Sodium Pertechnetate Tc 99m; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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