Document Detail


Spleen cell dialyzable extracts (SCDE) mediated immunotherapy for patients with myasthenia gravis.
MedLine Citation:
PMID:  1761349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied 14 cases of myasthenia gravis (MG) with regard to their anti-acetylcholine receptor antibody (AChR-Ab) production, peripheral blood CD4+/CD8+ ratio, and responses of peripheral lymphocytes to PHA and PWM stimulations. We found that the clinical severity was not proportional to AChR-Ab level in serum in terms of whole myasthenic population, whereas in one individual patient there was a close correlation between clinical severity and the AChR-Ab level in serum. The CD4+/CD8+ ratio in myasthenic patients was significantly higher than that of normal controls. The responses of T- and B-cells to mitogenic stimulations were impaired in myasthenic patients. The immune abnormalities found in the majority of the patients were restored to about normal after spleen cell dialyzable extracts (SCDE) therapy was applied to all patients. The results implicated that SCDE, working as an immunomodulator, could serve as a promising agent to normalize the abnormal immune functions of MG patients or other autoimmune diseases.
Authors:
B Z Yang; Z L Li; Z Y Cui; Y M Luo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of immunopharmacology     Volume:  13     ISSN:  0192-0561     ISO Abbreviation:  Int. J. Immunopharmacol.     Publication Date:  1991  
Date Detail:
Created Date:  1992-02-07     Completed Date:  1992-02-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7904799     Medline TA:  Int J Immunopharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  825-9     Citation Subset:  IM; X    
Affiliation:
Department of Immunology and Microbiology, Weifang Medical College, Shandong, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / isolation & purification,  therapeutic use
Autoantibodies / blood
CD4-CD8 Ratio
DNA / biosynthesis
Dialysis
Humans
Immunotherapy*
Lymphocyte Activation
Lymphocytes / immunology,  metabolism
Myasthenia Gravis / blood,  immunology,  therapy*
Receptors, Cholinergic / immunology
Spleen / immunology*
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Autoantibodies; 0/Receptors, Cholinergic; 9007-49-2/DNA

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