Document Detail

Spleen R2 and R2* in iron-overloaded patients with sickle cell disease and thalassemia major.
MedLine Citation:
PMID:  19161188     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the magnetic properties of the spleen in chronically transfused, iron-overloaded patients with sickle cell disease (SCD) and thalassemia major (TM) and to compare splenic iron burdens to those in the liver, heart, pancreas, and kidneys.
MATERIALS AND METHODS: A retrospective analysis of 63 TM and 46 SCD patients was performed. Spleen R2 and R2* values were calculated from spin-echo and gradient-echo images collected between April 2004 and September 2007.
RESULTS: The spleen showed a different R2-R2* relationship than that previously established for the liver. At high iron concentrations (R2* > 300 Hz), spleen R2 was lower than predicted for liver. The proportion of splenic to hepatic iron content was greater in SCD patients compared with TM patients (23.8% vs. 13.8%). A weak association was found between splenic and liver iron-this association was stronger in SCD patients. Little correlation was found between splenic iron and extrahepatic R2* values.
CONCLUSION: For spleen and liver tissue with the same R2* value, splenic R2 was significantly lower than hepatic R2, particularly for R2* > approximately 300 Hz. Splenic iron levels have little predictive value for R2* values of heart, pancreas, and kidney.
Casey J Brewer; Thomas D Coates; John C Wood
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  29     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-28     Completed Date:  2009-03-31     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  357-64     Citation Subset:  IM    
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MeSH Terms
Anemia, Sickle Cell / complications*
Child, Preschool
Image Processing, Computer-Assisted
Iron Overload / complications*
Kidney / chemistry
Liver / chemistry
Magnetic Resonance Imaging / methods*
Myocardium / chemistry
Pancreas / chemistry
Regression Analysis
Retrospective Studies
Spleen / chemistry*
beta-Thalassemia / complications*
Grant Support
1 R01 HL075592-01A1/HL/NHLBI NIH HHS; M01 RR000043/RR/NCRR NIH HHS; M01 RR000043-498714/RR/NCRR NIH HHS; R01 HL075592/HL/NHLBI NIH HHS; R01 HL075592-04/HL/NHLBI NIH HHS; RR000043-43/RR/NCRR NIH HHS; U27/CCU922106//PHS HHS

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