| Splanchnic transplantation. An approach to the infant dependent on parenteral nutrition who develops irreversible liver disease. | |
| | |
MedLine Citation:
|
PMID: 2537436 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Two infants with short-bowel syndrome and liver failure associated with obligatory parenteral nutrition received a composite allograft that consisted of en bloc liver, stomach, duodenum, pancreas, jejunum, and ileum. Solutions to the fatal complications in the first case resulted in a functioning composite splanchnic system in the second case. Despite a number of early complications, the small intestine and liver developed near-normal function until a monoclonal, malignant, B-cell lymphoproliferative disorder appeared. The analysis of these two cases supports three summary observations: the operative procedure can be safely performed in a metabolically compromised infant; intestinal allograft rejection, in this model, is controllable with existing immunosuppressive drugs; and this procedure appears to be associated with a uniquely high incidence of lymphoma. Since transplantation is a feasible solution to this devastating infantile disease, further development of this therapy must incorporate means of preventing lymphoma. |
| | |
Authors:
|
J W Williams; H N Sankary; P F Foster; J M Loew; G M Goldman; J Lowe |
Related Documents
:
|
22752776 - An open-label, randomized efficacy and safety trial of subcutaneous and intramuscular b... 803386 - Cholestasis in immature newborn infants: is parenteral alimentation responsible? 17044896 - Low incidence of alpha 1-antitrypsin deficiency among filipinos with neonatal cholestatis. 7521396 - Extrahepatic biliary atresia: a first-trimester event? clues from light microscopy and ... 1897366 - Evoked otoacoustic emissions from normal newborns and babies admitted to an intensive c... 11124916 - Randomised controlled trial of oral vitamin a supplementation in preterm infants to pre... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: JAMA : the journal of the American Medical Association Volume: 261 ISSN: 0098-7484 ISO Abbreviation: JAMA Publication Date: 1989 Mar |
Date Detail:
|
Created Date: 1989-03-24 Completed Date: 1989-03-24 Revised Date: 2006-11-07 |
Medline Journal Info:
|
Nlm Unique ID: 7501160 Medline TA: JAMA Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1458-62 Citation Subset: AIM; IM |
Affiliation:
|
Department of General Surgery, Rush-Presbyterian-St Luke's Medical Center, Chicago, Ill 60612. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cyclosporins
/
administration & dosage,
pharmacokinetics Herpesvirus 4, Human Humans Infant Liver Diseases / etiology, surgery* Lymphoproliferative Disorders / immunology*, pathology Male Parenteral Nutrition* Postoperative Complications* / pathology Short Bowel Syndrome / etiology, surgery Viscera / transplantation* |
| Chemical | |
Reg. No./Substance:
|
0/Cyclosporins |
| Comments/Corrections | |
Erratum In:
|
JAMA 1989 Jul 14;262(2):210 Note: Lowe J [corrected to Loew JM] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cellular, enzymatic, and genetic factors in the pathogenesis of abdominal aortic aneurysms.
Next Document: Management of varicella exposure in a neonatal intensive care unit.