| Splanchnic and systemic vasodilation: the experimental models. | |
| | |
MedLine Citation:
|
PMID: 17975477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Experimental models are a sine qua non condition for unraveling the specific components and mechanisms contributing to vascular dysfunction and arterial vasodilation in portal hypertension. Moreover, a careful selection of the type of animal model, vascular bed, and methodology is crucial for any investigation of this issue. In this review, some critical aspects related to experimental models in portal hypertension and the techniques applied are highlighted. In addition, a detailed summary of the mechanisms of arterial vasodilation in portal hypertension is presented. First, humoral and endothelial vasodilators, predominantly nitric oxide but also carbon monoxide and endothelium-derived hyperpolarizing factor, and others are discussed. Second, time course and potential stimuli triggering and/or perpetuating splanchnic vasodilation are delineated. Finally, a brief general overview of vascular smooth muscle signaling sets the stage for a discussion on cotransmission, receptor desensitization, and the observed impairment in vasoconstrictor-induced smooth muscle contraction in the splanchnic and systemic circulation during portal hypertension. |
| | |
Authors:
|
Reiner Wiest |
Related Documents
:
|
18209957 - Vascular adaptation and mechanical homeostasis at tissue, cellular, and sub-cellular le... 16837917 - Novel aspects of endothelium-dependent regulation of vascular tone. 14597887 - Prediction of sites of coronary atherosclerosis progression: in vivo profiling of endot... 16491837 - Role of interleukin-4 in atherosclerosis. 1534317 - Atrial natriuretic polypeptide as a novel antigrowth factor of endothelial cells. 12063547 - Thiazolidinedione, a peroxisome proliferator-activated receptor-gamma ligand, modulates... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Journal of clinical gastroenterology Volume: 41 Suppl 3 ISSN: 0192-0790 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 2007 Nov-Dec |
Date Detail:
|
Created Date: 2007-11-02 Completed Date: 2008-02-06 Revised Date: 2008-07-10 |
Medline Journal Info:
|
Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: United States |
Other Details:
|
Languages: eng Pagination: S272-87 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine I, University Regensburg, Bavaria, Germany. t@klinik.uni-regensburg.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arteries / metabolism, physiopathology Biological Factors / metabolism Carbon Monoxide / metabolism Disease Models, Animal Endothelium, Vascular / metabolism, physiopathology Humans Hypertension, Portal / metabolism, physiopathology* Muscle, Smooth, Vascular / metabolism, physiopathology Nitric Oxide / metabolism Research Design Signal Transduction Splanchnic Circulation* Time Factors Vasoconstriction Vasoconstrictor Agents / metabolism Vasodilation* Vasodilator Agents / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Biological Factors; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 0/endothelium-dependent hyperpolarization factor; 10102-43-9/Nitric Oxide; 630-08-0/Carbon Monoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Splanchnic and systemic vasodilatation: the patient.
Next Document: The molecules: mechanisms of arterial vasodilatation observed in the splanchnic and systemic circula...