Document Detail

Splanchnic metabolism of ingested amino acids in neonates.
MedLine Citation:
PMID:  17143056     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Neonates typically show rapid growth. Nutrient absorption in the neonatal period is higher than during any other time in life so as to meet the requirements for this rapid growth. Generally, nutrients are administered enterally, and in the past the gut was considered to absorb and digest these nutrients without major metabolism. Recent animal and human work has, however, revealed that the intestine and other splanchnic tissues contribute significantly to whole-body metabolism, and have their own specific functions. This review focuses on these observations. RECENT FINDINGS: The splanchnic tissues take up greatly different proportions of each of the amino acids, ranging from 80-100% for threonine and several nonessential amino acids to 15-30% for lysine. The metabolic fates of the utilized substrates differ as well. Some are predominantly used for constitutive protein synthesis, others for energy generation or for formation of (glyco-)proteins that are secreted into the lumen. Glucose appears to be the major contributor to energy generation, but amino acids are important as well. SUMMARY: Both animal and human studies have shown that the intestine uses substantial amounts of dietary amino acids. This has several implications for the nutritional needs of infants to maintain growth, especially during times of inadequate enteral nutrition.
Maaike A Riedijk; Johannes B van Goudoever
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  10     ISSN:  1363-1950     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-04     Completed Date:  2007-03-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  58-62     Citation Subset:  IM    
Erasmus MC-Sophia Children's Hospital, Department of Pediatrics, Division of Neonatology, Rotterdam, The Netherlands.
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MeSH Terms
Amino Acids / administration & dosage*,  metabolism*
Biological Availability
Infant Nutritional Physiological Phenomena*
Infant, Newborn / growth & development*,  metabolism*
Intestinal Absorption
Intestine, Small / metabolism
Nutritional Requirements
Viscera / metabolism
Reg. No./Substance:
0/Amino Acids

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