Document Detail


Splanchnic and hepatic metabolism of somatostatin: a study in cirrhotic patients with a portacaval shunt.
MedLine Citation:
PMID:  6131859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Experimental data suggest that somatostatin is metabolized by both liver and kidneys. Results in humans are conflicting. By studying a group of cirrhotic patients with surgically induced end-to-side portacaval shunts, basally and during a somatostatin infusion, we have been able to analyze separately the hepatic and splanchnic metabolism of this peptide. After catheterization, samples were obtained from the pulmonary artery, portal and hepatic veins. Basal pulmonary artery immunoreactive somatostatin (IRS) was significantly higher (p less than 0.001) in the cirrhotic patients (96 +/- 11 pg per ml) than in a sex- and age-matched control group (31.4 +/- 5.8 pg per ml). During the infusion of exogenous somatostatin, IRS values were higher in arterial (12,269 +/- 1,198 pg per ml) than in hepatic venous blood (7,648 +/- 1,234 pg per ml), indicating hepatic extraction of the peptide; but there was also a substantial splanchnic extraction demonstrated by higher arterial (12,269 +/- 1,532 pg per ml) than portal values (6,754 +/- 1,040 pg per ml) of IRS. During the somatostatin infusion, at very high circulation IRS levels, the liver was able to extract 38% of the peptide. This suggests that the high basal IRS levels found in liver cirrhosis are not likely to be due to hepatic failure. Possible mechanisms may involve increased somatostatin secretion, predominance of high molecular weight moieties of IRS which may not be as effectively removed by the liver, and/or portal-systemic shunting.
Authors:
S Webb; D Kravetz; J Bosch; J A Wass; J Evans; R Gomis; L H Rees; J Rodés
Related Documents :
14755789 - Hepatic arterial anatomy for right liver procurement from living donors.
11059229 - Two anomalous cases of the hepato-mesenteric and the gastro-splenic trunks independentl...
4007699 - Pathology of the migration phase of taenia hydatigena (pallas, 1766) larvae.
9694469 - Effects of injection rates of contrast material on arterial phase hepatic ct.
6163219 - Indications for cholecystectomy in ligation of the hepatic artery.
3782269 - Pulmonary embolism from a parasitic cardiac clot secondary to hepatic alveolar echinoco...
21646029 - Endovascular stenting of extracranial carotid artery aneurysm: a systematic review.
20704929 - Mechanism of disease: pulmonary hypertension.
8604959 - Diagnosis of pulmonary embolism by a decision analysis-based strategy including clinica...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  3     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:    1983 Mar-Apr
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  193-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Arteriovenous Shunt, Surgical
Female
Hepatic Veins
Humans
Infusions, Parenteral
Liver / blood supply,  metabolism*
Liver Cirrhosis / metabolism*
Male
Metabolic Clearance Rate
Middle Aged
Portal Vein
Pulmonary Artery
Somatostatin / administration & dosage,  metabolism*
Spleen / blood supply,  metabolism*
Chemical
Reg. No./Substance:
51110-01-1/Somatostatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Therapy of duodenal ulcer with H2-blockers. 2 x 150 mg ranitidine versus 2 x 400 mg cimetidine
Next Document:  Differential effects of oral contraceptive steroids on the metabolism of benzodiazepines.