Document Detail

Splanchnic haemodynamics in patients with coeliac disease: effects of a gluten-free diet.
MedLine Citation:
PMID:  12801038     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Coeliac disease is characterized by structural and functional changes in the small bowel which may also result in haemodynamic changes. AIMS: To establish whether splanchnic haemodynamics can be modified by a gluten-free diet. PATIENTS: Ten coeliac patients and 10 paired healthy subjects. METHODS: Echo-Doppler measurements were made of splanchnic vessels both fasting and after a standard meal before and after 9 months of a gluten-free diet. RESULTS: In comparison to controls, coeliac patients had higher superior mesenteric artery blood velocity and flow, with lower resistance indexes and higher portal vein velocity and flow, particularly 3 h after a meal. Postprandial hyperaemia was reduced and delayed in time. Intrasplenic resistance indexes were also significantly lower both fasting and after a meal. After 9 months of a gluten-free diet, no significant differences were observed between coeliac patients and controls, both fasting and after a meal. CONCLUSIONS: Splanchnic haemodynamics is significantly changed in coeliac patients, mainly after a meal. On treatment with a gluten-free diet, both fasting and postprandial haemodynamics became normal.
D Magalotti; U Volta; A Bonfiglioli; S Ramilli; A Berzigotti; M Zoli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  35     ISSN:  1590-8658     ISO Abbreviation:  Dig Liver Dis     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-06-12     Completed Date:  2003-07-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  262-8     Citation Subset:  IM    
Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, Policlinico S. Orsola-Malpighi, Via Massarenti 9, 40138 Bologna, Italy.
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MeSH Terms
Blood Flow Velocity
Case-Control Studies
Celiac Disease / diet therapy*,  physiopathology*,  ultrasonography
Echocardiography, Doppler
Fasting / physiology
Glutens / administration & dosage
Hyperemia / physiopathology
Liver / blood supply
Mesenteric Artery, Superior / physiopathology,  ultrasonography
Middle Aged
Portal Vein / physiopathology,  ultrasonography
Postprandial Period / physiology
Pulsatile Flow / physiology
Splanchnic Circulation / physiology*
Spleen / blood supply
Time Factors
Vascular Resistance / physiology
Reg. No./Substance:

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