Document Detail

Splanchnic concentrations and postprandial release of visceral adipokines.
MedLine Citation:
PMID:  19913846     Owner:  NLM     Status:  MEDLINE    
No detailed data are available on hepatic clearance, postprandial release, and distribution profile of metabolically active adipokines in splanchnic blood compartments such as portal and hepatic veins. This would be a prerequisite for understanding the role of visceral adipose tissue-derived adipokines in metabolism. Adiponectin, resistin, leptin, and visfatin concentrations were measured by enzyme-linked immunosorbent assay in peripheral veins, arterial blood, hepatic veins, and portal veins in 50 patients with liver cirrhosis undergoing transjugular intrahepatic portosystemic shunt implantation, in 6 patients with normal liver function, and in fasted and fed rats. Adiponectin, leptin, resistin, and visfatin did not differ among blood compartments in normal-weight probands in the fasted state. Adiponectin and leptin levels were similar in patients with and without liver cirrhosis. Systemic visfatin levels were decreased and resistin levels were increased in liver cirrhosis. Visfatin secretion was higher from visceral than from peripheral subcutaneous adipose tissue in liver cirrhosis. There was no hepatic clearance of visfatin. Leptin secretion was higher from peripheral than from visceral adipose tissue. Leptin did not undergo hepatic clearance. Resistin and adiponectin did not differ between blood compartments in liver cirrhosis. Resistin concentrations increased upon feeding in rats, and there was an increase in the postprandial clearance of adiponectin by the liver. A postprandial increase of leptin concentrations was restricted to peripheral adipose tissue in rats. The results give insight into the dynamics of splanchnic adipokine concentrations and help critically interpret data derived from messenger RNA expression studies.
Reiner Wiest; Lukas Moleda; Stefan Farkas; Markus Scherer; Andrea Kopp; Ulrike W?nckhaus; Christa B?chler; J?rgen Sch?lmerich; Andreas Sch?ffler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-14
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  59     ISSN:  1532-8600     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-19     Completed Date:  2010-05-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  664-70     Citation Subset:  IM    
Department of Internal Medicine I, University Hospital of Regensburg, Regensburg, Germany.
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MeSH Terms
Adipokines / blood*
Adiponectin / blood
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Hepatic Veins / metabolism
Intra-Abdominal Fat / metabolism*
Leptin / blood
Liver / blood supply*,  metabolism*
Liver Cirrhosis / metabolism
Middle Aged
Nicotinamide Phosphoribosyltransferase / blood
Portal Vein / metabolism
Postprandial Period
Rats, Sprague-Dawley
Resistin / blood
Splanchnic Circulation
Statistics, Nonparametric
Reg. No./Substance:
0/Adipokines; 0/Adiponectin; 0/Leptin; 0/Resistin; EC Phosphoribosyltransferase

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