Document Detail


Splanchnic buffering of metabolic acid during early endotoxemia.
MedLine Citation:
PMID:  9075059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: We sought to determine the sites of metabolic acid production and clearance during acute endotoxemia. MATERIALS AND METHODS: In 10 pentobarbital-anesthetized dogs, flow was measured (ultrasonic probes) for the protal vein, hepatic artery, and renal artery. Catheters were inserted into the hepatic vein, pulmonary artery, renal vein and portal vein. Measurements of blood gases and strong ions were obtained from each site during control conditions and after 30 minutes of intravenous infusion of 1 mg/kg of Escherichia coli endotoxin. The total metabolic acid flux across each organ was calculated using the standard base excess formula and the effective strong ion difference method. PaCO2 was maintained by controlled ventilation. RESULTS: Mean arterial pH decreased from 7.34 to 7.22 with acute endotoxemia. Although transvisceral pH gradients revealed net acid release, the source of this was purely respiratory (carbon dioxide). During early endotoxemia, the gut significantly increased metabolic acid uptake (36.60 +/- 6.60 mmol/h, P < .05). CONCLUSIONS: We conclude that during early endotoxemia in the dog, the gut is a major site of metabolic acid removal.
Authors:
J A Kellum; R Bellomo; D J Kramer; M R Pinsky
Related Documents :
5901159 - Effect of dichlorphenamide on gas exchange and csf acid-base state in chronic respirato...
17548219 - The effects on maternal and fetal cardiovascular and acid-base variables after the admi...
27849 - Intracellular acid-base state at a variable temperature in air-breathing vertebrates an...
11112169 - Insect acid-base physiology.
18402889 - Fluid therapy in vomiting and diarrhea.
22252009 - Amino acids downregulate the expression of several autophagy-related genes in rainbow t...
20702949 - Determination of fatty acids in human sweat during fasting using gc/ms.
19604939 - Amino acid inhibition of sodium-dependent synaptosomal proline uptake.
3935039 - A population study of alpha-keto acid reductase.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of critical care     Volume:  12     ISSN:  0883-9441     ISO Abbreviation:  J Crit Care     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-05-22     Completed Date:  1997-05-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8610642     Medline TA:  J Crit Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  7-12     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology/CCM, University of Pittsburgh Medical Center, PA 15213-2582, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acid-Base Equilibrium*
Acidosis / etiology*,  metabolism*
Acute Disease
Animals
Disease Models, Animal
Dogs
Endotoxemia / complications*
Escherichia coli Infections / complications*
Intestines / metabolism
Kidney / metabolism
Liver / metabolism
Male
Metabolic Clearance Rate
Splanchnic Circulation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The early relationship of drug abusing mothers and their infants: an assessment at eight to twelve m...
Next Document:  Tracheal gas insufflation improves ventilatory efficiency during metacholine-induced bronchospasm.