Document Detail

Splanchnic buffering of metabolic acid during early endotoxemia.
MedLine Citation:
PMID:  9075059     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We sought to determine the sites of metabolic acid production and clearance during acute endotoxemia. MATERIALS AND METHODS: In 10 pentobarbital-anesthetized dogs, flow was measured (ultrasonic probes) for the protal vein, hepatic artery, and renal artery. Catheters were inserted into the hepatic vein, pulmonary artery, renal vein and portal vein. Measurements of blood gases and strong ions were obtained from each site during control conditions and after 30 minutes of intravenous infusion of 1 mg/kg of Escherichia coli endotoxin. The total metabolic acid flux across each organ was calculated using the standard base excess formula and the effective strong ion difference method. PaCO2 was maintained by controlled ventilation. RESULTS: Mean arterial pH decreased from 7.34 to 7.22 with acute endotoxemia. Although transvisceral pH gradients revealed net acid release, the source of this was purely respiratory (carbon dioxide). During early endotoxemia, the gut significantly increased metabolic acid uptake (36.60 +/- 6.60 mmol/h, P < .05). CONCLUSIONS: We conclude that during early endotoxemia in the dog, the gut is a major site of metabolic acid removal.
J A Kellum; R Bellomo; D J Kramer; M R Pinsky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of critical care     Volume:  12     ISSN:  0883-9441     ISO Abbreviation:  J Crit Care     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-05-22     Completed Date:  1997-05-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8610642     Medline TA:  J Crit Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  7-12     Citation Subset:  IM    
Department of Anesthesiology/CCM, University of Pittsburgh Medical Center, PA 15213-2582, USA.
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MeSH Terms
Acid-Base Equilibrium*
Acidosis / etiology*,  metabolism*
Acute Disease
Disease Models, Animal
Endotoxemia / complications*
Escherichia coli Infections / complications*
Intestines / metabolism
Kidney / metabolism
Liver / metabolism
Metabolic Clearance Rate
Splanchnic Circulation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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