Document Detail

Spirostanol pentaglycosides from the underground parts of polianthestuberosa.
MedLine Citation:
PMID:  12398537     Owner:  NLM     Status:  MEDLINE    
Phytochemical analysis of the underground parts of Polianthes tuberosa has resulted in the isolation of four new spirostanol saponins with five monosaccharides (1-4). Their structures were determined by spectroscopic analysis, including extensive 1D and 2D NMR data, and the results of hydrolytic cleavage. The cytotoxic activities of 1-4 against HL-60 human promyelocytic leukemia cells and HSC-2 human oral squamous cell carcinoma cells are reported.
Yoshihiro Mimaki; Akihito Yokosuka; Chiseko Sakuma; Hiroshi Sakagami; Yutaka Sashida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of natural products     Volume:  65     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-25     Completed Date:  2002-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1424-8     Citation Subset:  IM    
School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1, Horinouchi, Hachioji, Japan.
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MeSH Terms
Agavaceae / chemistry*
Antineoplastic Agents, Phytogenic / chemistry,  isolation & purification,  pharmacology
Carbohydrate Sequence
Drug Screening Assays, Antitumor
Glycosides / chemistry,  isolation & purification*,  pharmacology
Molecular Sequence Data
Saponins / chemistry,  isolation & purification*,  pharmacology
Spectrum Analysis
Tumor Cells, Cultured
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Glycosides; 0/Saponins

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