Document Detail

Spiroquinazoline, a novel substance P inhibitor with a new carbon skeleton, isolated from Aspergillus flavipes.
MedLine Citation:
PMID:  7517439     Owner:  NLM     Status:  MEDLINE    
A novel substance P inhibitor, spiroquinazoline [1], was isolated from the fungus Aspergillus flavipes, which was originally obtained from soil. The structure of 1 was determined by analysis of spectroscopic data and 1 was shown to contain a new carbon skeleton containing a spiro-carbon center. Also isolated from the same culture extract were the new natural product, benzodiazepiedione [3], and the known compounds, acyl aszonalenin [4], N-benzoyl-L-phenylalaninol, and seven diketopiperazines.
C J Barrow; H H Sun
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of natural products     Volume:  57     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-08-02     Completed Date:  1994-08-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  471-6     Citation Subset:  IM    
Natural Products Chemistry, Sterling Winthrop Pharmaceuticals Research Division, Malvern, PA 19355.
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MeSH Terms
Antineoplastic Agents / chemistry,  isolation & purification*,  pharmacology
Aspergillus / chemistry*
Astrocytoma / metabolism
Drug Screening Assays, Antitumor
Magnetic Resonance Spectroscopy
Nervous System Neoplasms / metabolism
Receptors, Neurokinin-1 / drug effects
Spectrophotometry, Ultraviolet
Spiro Compounds / chemistry,  isolation & purification*,  pharmacology
Substance P / antagonists & inhibitors*
Tumor Cells, Cultured
Reg. No./Substance:
0/Antineoplastic Agents; 0/Receptors, Neurokinin-1; 0/Spiro Compounds; 157075-58-6/spiroquinazoline; 33507-63-0/Substance P

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