Document Detail


Spiroquinazoline, a novel substance P inhibitor with a new carbon skeleton, isolated from Aspergillus flavipes.
MedLine Citation:
PMID:  7517439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel substance P inhibitor, spiroquinazoline [1], was isolated from the fungus Aspergillus flavipes, which was originally obtained from soil. The structure of 1 was determined by analysis of spectroscopic data and 1 was shown to contain a new carbon skeleton containing a spiro-carbon center. Also isolated from the same culture extract were the new natural product, benzodiazepiedione [3], and the known compounds, acyl aszonalenin [4], N-benzoyl-L-phenylalaninol, and seven diketopiperazines.
Authors:
C J Barrow; H H Sun
Related Documents :
24212689 - Antifouling activity of twelve demosponges from brazil.
24335269 - Latitudinal gradients in intraspecific ecological diversity.
23439139 - Robust technique using an imaging plate to detect environmental radioactivity.
23517889 - Microbial degradation of steroidal estrogens.
23533619 - Effect of sugarcane burning or green harvest methods on the brazilian cerrado soil bact...
23095999 - Phenotypic and developmental plasticity of xylem in hybrid poplar saplings subjected to...
22049939 - Dissimilatory ammonia production vs. denitrification in vitro and in inoculated agricul...
10820119 - Bioremediation of olive oil mill wastewater: chemical alterations induced by azotobacte...
10888559 - Composition of essential oil of costmary [balsamita major (l.) desf. ] at different gro...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of natural products     Volume:  57     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-08-02     Completed Date:  1994-08-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  471-6     Citation Subset:  IM    
Affiliation:
Natural Products Chemistry, Sterling Winthrop Pharmaceuticals Research Division, Malvern, PA 19355.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / chemistry,  isolation & purification*,  pharmacology
Aspergillus / chemistry*
Astrocytoma / metabolism
Drug Screening Assays, Antitumor
Humans
Magnetic Resonance Spectroscopy
Nervous System Neoplasms / metabolism
Receptors, Neurokinin-1 / drug effects
Spectrophotometry, Ultraviolet
Spiro Compounds / chemistry,  isolation & purification*,  pharmacology
Stereoisomerism
Substance P / antagonists & inhibitors*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Receptors, Neurokinin-1; 0/Spiro Compounds; 157075-58-6/spiroquinazoline; 33507-63-0/Substance P

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Neurite outgrowth from cultured CNS neurons is promoted by inhibitors of protein and RNA synthesis.
Next Document:  Mast cells in experimental allergic encephalomyelitis: characterization, distribution in the CNS and...