Document Detail

Spironolactone and captopril attenuates isoproterenol-induced cardiac remodelling in rats.
MedLine Citation:
PMID:  11592866     Owner:  NLM     Status:  MEDLINE    
The role of renin-angiotensin-aldosterone system in cardiac remodelling was studied in isoproterenol-induced cardiac hypertrophy in rats. The effects of captopril and spironolactone were compared. Isoproterenol treatment increased ventricular to body weight ratio (4.6 vs 3.7) and collagen area (22.6 vs 8.2%), and reduced systolic (89.93 vs 107.5 mm Hg) and diastolic (59.6 vs 70.8 mm Hg) pressure. In these animals, captopril decreased systolic (67.4 mm Hg) and diastolic pressure (31.9 mm Hg), whereas spironolactone regressed systolic pressure to control values (101.2 mm Hg). Captopril and spironolactone prevented cardiac hypertrophy (4.01 and 3.95). However, only spironolactone prevented myocardial fibrosis (11.3%).
M Gallego; L Espiña; L Vegas; E Echevarria; M M Iriarte; O Casis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  44     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-10     Completed Date:  2002-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  311-5     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Academic Press.
Department of Physiology, School of Pharmacy, University of the Basque Country, Spain.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Blood Pressure / drug effects
Captopril / pharmacology*
Cardiomegaly / chemically induced,  prevention & control*
Collagen / drug effects
Dose-Response Relationship, Drug
Endomyocardial Fibrosis / chemically induced,  prevention & control*
Heart Ventricles / drug effects
Myocardium / pathology
Organ Size / drug effects
Rats, Sprague-Dawley
Spironolactone / pharmacology*
Ventricular Remodeling / drug effects*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 52-01-7/Spironolactone; 62571-86-2/Captopril; 7683-59-2/Isoproterenol; 9007-34-5/Collagen

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