| Spironolactone and captopril attenuates isoproterenol-induced cardiac remodelling in rats. | |
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MedLine Citation:
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PMID: 11592866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of renin-angiotensin-aldosterone system in cardiac remodelling was studied in isoproterenol-induced cardiac hypertrophy in rats. The effects of captopril and spironolactone were compared. Isoproterenol treatment increased ventricular to body weight ratio (4.6 vs 3.7) and collagen area (22.6 vs 8.2%), and reduced systolic (89.93 vs 107.5 mm Hg) and diastolic (59.6 vs 70.8 mm Hg) pressure. In these animals, captopril decreased systolic (67.4 mm Hg) and diastolic pressure (31.9 mm Hg), whereas spironolactone regressed systolic pressure to control values (101.2 mm Hg). Captopril and spironolactone prevented cardiac hypertrophy (4.01 and 3.95). However, only spironolactone prevented myocardial fibrosis (11.3%). |
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Authors:
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M Gallego; L Espiña; L Vegas; E Echevarria; M M Iriarte; O Casis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacological research : the official journal of the Italian Pharmacological Society Volume: 44 ISSN: 1043-6618 ISO Abbreviation: Pharmacol. Res. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-10 Completed Date: 2002-01-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8907422 Medline TA: Pharmacol Res Country: England |
Other Details:
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Languages: eng Pagination: 311-5 Citation Subset: IM |
Copyright Information:
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Copyright 2001 Academic Press. |
Affiliation:
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Department of Physiology, School of Pharmacy, University of the Basque Country, Spain. mongallego@yahoo.es |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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pharmacology* Animals Blood Pressure / drug effects Captopril / pharmacology* Cardiomegaly / chemically induced, prevention & control* Collagen / drug effects Dose-Response Relationship, Drug Endomyocardial Fibrosis / chemically induced, prevention & control* Heart Ventricles / drug effects Isoproterenol Myocardium / pathology Organ Size / drug effects Rats Rats, Sprague-Dawley Spironolactone / pharmacology* Ventricular Remodeling / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 52-01-7/Spironolactone; 62571-86-2/Captopril; 7683-59-2/Isoproterenol; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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