| Spirometry and diffusion studies in patients with type-2 diabetes mellitus and their association with microvascular complications. | |
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MedLine Citation:
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PMID: 21302598 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Diabetes is a systemic disease with-well known complications involving eyes, kidneys and nerves. The presence of an extensive pulmonary microvascular circulation and abundant connective tissue raises the possibility that lung may also be a target organ in diabetes. METHODS: A total of 45 subjects were included in the study. All patients were evaluated for diabetic microangiopathies: nephropathy (by 24-hour protein excretion), retinopathy (by direct ophthalmoscopy) and neuropathy (by clinical examination). The patients were divided into following three groups: Group A: patients with type-2 diabetes mellitus (DM) with evidence of microangiopathy (n=15); Group B: patients with type-2 DM without any evidence of microangiopathy (n=15); Group C: non-diabetic subjects (n=15) as controls. Glycosylated haemoglobin (HbA1C) was measured as an indicator of glycemic control. Spirometry and single-breath diffusion capacity for carbon-monoxide (DLCO) were performed on all patients using Elite Series Body Plethysmograph machine. RESULTS: A significant reduction of diffusion capacity corrected for alveolar volume (%DL/VA) was observed in group A (p < 0.001), as compared to the other groups. There were no differences among the three groups for other pulmonary functions. There was a significant correlation between DL/VA percent predicted and albuminuria (r= -0.975, p < 0.001), and DL/VA percent predicted and the retinopathy (r = -0.550, p < 0.05). CONCLUSION: This study shows a mild reduction in diffusing capacity in patients with type-2 DM with microangiopathy. |
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Authors:
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A S Agarwal; A B Fuladi; G Mishra; B O Tayade |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Indian journal of chest diseases & allied sciences Volume: 52 ISSN: 0377-9343 ISO Abbreviation: Indian J Chest Dis Allied Sci Publication Date: 2010 Oct-Dec |
Date Detail:
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Created Date: 2011-02-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7612044 Medline TA: Indian J Chest Dis Allied Sci Country: India |
Other Details:
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Languages: eng Pagination: 213-6 Citation Subset: IM |
Affiliation:
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Department of Chest Medicine and Tuberculosis, Government Medical College, Nagpur, Maharashtra, India. doc.amitagarwal@gmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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