| Spirometric parameters and levels of interferon gamma and IL-5 in induced sputum from patients with allergic rhinitis or asthma. | |
| | |
MedLine Citation:
|
PMID: 22186238 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: This study was designed to analyze spirometric parameters and cytokine (interferon [IFN] gamma and IL-5) levels in induced sputum from patients with asthma or allergic rhinitis (AR) and nonatopic subjects. METHODS: Thirty-three subjects aged 18-60 years were enrolled in the present study. Eight patients had asthma without AR symptoms, 16 had AR without asthma symptoms or history, and both groups had positive skin-prick test (SPT) to aeroallergens. The nine remaining subjects were healthy nonatopic subjects with negative SPT to aeroallergens. Spirometry was performed by evaluating the forced vital capacity (FVC), forced expiratory volume in the 1st second (FEV(1)), and forced expiratory flow between 25 and 75% (FEF(25-75)) of FVC before and after bronchodilator use. Induced sputum samples were also collected for measuring cytokine (IFN-gamma and IL-5) levels by enzyme-linked immunosorbent assay. RESULTS: Significant pre- and postbronchodilator change was observed only for FEV(1) with higher variation values in asthmatic subjects compared with patients with AR (p < 0.05) and nonatopic subjects (p < 0.01). There was no significant difference in pre- and postbronchodilator spirometric parameters among the three groups, although asthmatic patients showed lower prebronchodilator FEF(25-75) values (p = 0.065). IL-5 levels were higher in induced sputum from patients with asthma and AR compared with nonatopic subjects (p = 0.020 and p = 0.032, respectively), but IFN-gamma levels showed no significant difference between the groups. CONCLUSION: Spirometric measurements were not able to show any occurrence of bronchial constriction in patients with AR, but predominant IL-5 levels in induced sputum from these patients reinforce the role of Th2-type immune response in lower respiratory airways that could contribute to the concept of "one airway, one disease." |
| | |
Authors:
|
Sheila M G Marra; Rosiane O Borges; Ronaldo Alves; Deise A O Silva; Ernesto A Taketomi; Gesmar R S Segundo |
Related Documents
:
|
19411818 - Blood coagulation and fibrinolysis in patients with cushing's syndrome: increased plasm... 18078398 - Inhibitors in haemophilia a: current management and open issues. 6777018 - Plasma exchange and human factor viii concentrate in managing haemophilia a with factor... 12871398 - Inherited factor xi deficiency confers no protection against acute myocardial infarction. 6850258 - The influence of ultrasonic duplex scanning on the management of carotid artery disease. 17903828 - Spectrum of antiphospholipid antibodies (apl) in patients with cerebrovascular disease. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of rhinology & allergy Volume: 25 ISSN: 1945-8932 ISO Abbreviation: Am J Rhinol Allergy Publication Date: 2011 Sep-Oct |
Date Detail:
|
Created Date: 2011-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101490775 Medline TA: Am J Rhinol Allergy Country: United States |
Other Details:
|
Languages: eng Pagination: 196-9 Citation Subset: IM |
Affiliation:
|
Laboratory of Allergy and Clinical Immunology, Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, MG, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Histological features of the nasal mucosa in hematopoietic stem cell transplantation.
Next Document: Pathophysiology of chronic rhinosinusitis with nasal polyp.