| Spirometric and flow-volume curve analysis in rats, and optimal parameters for estimating obstructive impairment. | |
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MedLine Citation:
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PMID: 20549421 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We obtained flow-volume (F-V) curves in anesthetized rats by applying positive pressure on the body surface. To obtain the best curve, tracheal intubation with either a 12 or 13 gauge catheter and a surface pressure greater than 56 cmH(2)O was necessary. Peak expiratory flow rate (PEFR) and forced vital capacity (FVC) were shown to be optimal parameters for estimation of bronchoconstriction induced by methacholine inhalation while FEV(0.05) (forced expiratory volume at 0.05 s) and FEV(0.10) were of limited usefulness for this purpose. The descending segment of the F-V curve consisted of two or three phases, with later phases shortened during bronchoconstriction. In conclusion, PEFR and FVC are optimal parameters for estimation of bronchoconstriction in rats. The decreases in PEFR and FVC may reflect constriction in large and smaller airways, respectively. |
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Authors:
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Tetsuri Kondo; Toshimori Tanigaki; Chizuko Tsuji; Hidehiro Watanabe |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-12 |
Journal Detail:
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Title: The journal of physiological sciences : JPS Volume: 60 ISSN: 1880-6562 ISO Abbreviation: J Physiol Sci Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-18 Completed Date: 2010-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101262417 Medline TA: J Physiol Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 309-16 Citation Subset: IM |
Affiliation:
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Department of Respiratory Medicine, Tokai University Hachioji Hospital, Hachioji, Tokyo, 192-0032, Japan. tetsuri@hachioji-hosp.tokai.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Airway Obstruction
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diagnosis*,
physiopathology* Animals Bronchoconstriction Forced Expiratory Volume / drug effects Lung / physiopathology* Male Maximal Expiratory Flow-Volume Curves* Methacholine Chloride / pharmacology Peak Expiratory Flow Rate / drug effects Rats Rats, Wistar Spirometry / methods Vital Capacity* |
| Chemical | |
Reg. No./Substance:
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62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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