Document Detail


Spiral wave stability in cardiac tissue with biphasic restitution.
MedLine Citation:
PMID:  14525016     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human ventricular tissue as well as several animal ventricular preparations show a biphasic shape of the action potential duration restitution curve, with a local maximum at low diastolic intervals. We study numerically how the location and properties of this nonmonotonicity affect the stability of spiral waves. We find that, depending on the slopes of the ascending and of the descending parts of the restitution curve, we can have either stable rotation of the spiral wave or spiral breakup. We identify two types of spiral breakup: one due to a steep positive slope and another due to a steep negative slope in the restitution curve. We discuss the differences in their manifestation and possible implications. We also find that increasing the slope of the descending part of the restitution curve increases the meandering of the spiral wave, due to the repeated occurrence of conduction blocks near the spiral wave tip.
Authors:
O Bernus; H Verschelde; A V Panfilov
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Publication Detail:
Type:  Journal Article     Date:  2003-08-26
Journal Detail:
Title:  Physical review. E, Statistical, nonlinear, and soft matter physics     Volume:  68     ISSN:  1539-3755     ISO Abbreviation:  Phys Rev E Stat Nonlin Soft Matter Phys     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-10-03     Completed Date:  2004-02-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101136452     Medline TA:  Phys Rev E Stat Nonlin Soft Matter Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  021917     Citation Subset:  IM    
Affiliation:
Department of Mathematical Physics and Astronomy, Ghent University, Krijgslaan 281, 9000 Gent, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials
Biophysical Phenomena
Biophysics
Electrophysiologic Techniques, Cardiac
Heart / physiology*
Heart Conduction System
Humans
Ions
Models, Cardiovascular
Myocardium / metabolism*
Numerical Analysis, Computer-Assisted
Chemical
Reg. No./Substance:
0/Ions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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